SBi4211 dimethanesulfonate
| 中文名称 | SBi4211 dimethanesulfonate |
|---|---|
| 中文同义词 | 化合物HEPTAMIDINE DIMETHANESULFONATE;4,4'-(庚烷-1,7-二基双(氧基))二苯甲脒 二甲磺酸盐;二甲基磺酸庚胺 |
| 英文名称 | SBi4211 dimethanesulfonate |
| 英文同义词 | Heptamidine dimethanesulfonate;Heptamidine dimethanesulfote;SBi4211 dimethanesulfonate;4,4'-(Heptane-1,7-diylbis(oxy))dibenzimidamide dimethanesulfonate;Heptamidine,dystrophy,SBi 4211,Myotonic,SBi4211,inhibit,Calcium-Binding,cancer,melanoma,SBi-4211,S100B,Heptamidine dimethanesulfonate,HeLa,Inhibitor,cell |
| CAS号 | 161374-55-6 |
| 分子式 | C22H32N4O5S |
| 分子量 | 464.58 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 161374-55-6.mol |
| 结构式 |  |
SBi4211 dimethanesulfonate 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：62.5 mg/mL（111.47 mM） |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
Kd: 6.9 μM (calcium-binding protein S100B)
Heptamidine is a Pentamidine-S100B complex, two molecules of pentamidine bind per monomer of S100B, which performs to be an inhibitor for S100B.Heptamidine (20 μM) does not decrease CUG levels significantly when compares to Propamidine and Pentamidine, and exhibits cytotoxic at concentrations above 17.5 μM in HeLa cells expressing 960 CUG repeats.Heptamidine rescues mis-splicing of minigene reporters in a HeLa cell DM1 model with an EC 50 value of 15 μM.
Heptamidine (intraperitoneal injection; 20 or 30 mg/kg; 7 days) causes a dose-dependent reduction of exon 7a inclusion in HSA LR mice, returning to wild type levels (6±1%) when at 20 mg/kg dose, the myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 or 30 mg/kg.
| Animal Model: | Homozygous HSALR transgenic mice in line 20b (FVB inbred background) with a Myotonic dystrophy (DM) mouse model |
| Dosage: | 20 or 30 mg/kg |
| Administration: | Intraperitoneal injection; 7 days; once daily |
| Result: | Reversed splicing defects and rescues myotonia in a DM mouse model. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-16918A | SBi4211 dimethanesulfonate Heptamidine dimethanesulfonate | 161374-55-6 | 5mg | 2100元 |
| 2024/04/30 | S3389 | SBi4211 dimethanesulfonate Heptamidine Dimethanesulfonate | 161374-55-6 | 5mg | 2366.91元 |