| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:HWL-088;HWL088,HWL 088
CAS:2378617-96-8
Purity:98% Package:100 mg;25 mg;50 mg
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| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:HWL-088
CAS:2378617-96-8
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，more
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| | HWL-088 Basic information |
| Product Name: | HWL-088 | | Synonyms: | HWL-088;2-(2-fluoro-4-((2'-methyl-[1,1'-biphenyl]-3-yl)methoxy)phenoxy)acetic acid;HWL088,HWL 088;Acetic acid, 2-[2-fluoro-4-[(2'-methyl[1,1'-biphenyl]-3-yl)methoxy]phenoxy]- | | CAS: | 2378617-96-8 | | MF: | C22H19FO4 | | MW: | 366.38 | | EINECS: | | | Product Categories: | | | Mol File: | 2378617-96-8.mol |  |
| | HWL-088 Chemical Properties |
| Boiling point | 523.7±45.0 °C(Predicted) | | density | 1.241±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 250 mg/mL (682.35 mM; Need ultrasonic) | | form | Solid | | pka | 3.14±0.10(Predicted) | | color | White to off-white |
| | HWL-088 Usage And Synthesis |
| Biological Activity | HWL-088 is a highly potent and orally active free fatty acid receptor 1 (FFA1/GPR40) agonist (EC50 of 18.9 nM) with moderate PPARδ activity (EC50 of 570.9 nM) . HWL-088 improves glucose and lipid metabolism, and has anti-diabetic effects[1][2].
HWL-088 (0.3 μM and 3μM) significantly increases insulin secretion fromMIN6 cells at 25 mM but not at 2 mM glucose. HWL-088 reveales a dose-dependent insulinotropic effect in the presence of 25-mM glucose[2].
HWL-088 (40 mg/kg; oral gavage; daily; for 30 days; ob/ob mice) treatment improves β-cell function by up-regulation of pancreas duodenum homeobox-1, reduces fat accumulation in adipose tissue and alleviated fatty liver in ob/ob mice. The effect of HWL-088 involves a reduction in hepatic lipogenesis and oxidative stress, increased lipoprotein lipolysis, glucose uptake, mitochondrial function and fatty acid β-oxidation[2]. | | References | [1]. Li Z, et al. Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold. Bioorg Chem. 2019 Nov;92:103209. [2]. Yueming Chen, et al. HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice. Br J Pharmacol. 2020 May;177(10):2286-2302. |
| | HWL-088 Preparation Products And Raw materials |
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