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| | NSC 377363 Basic information |
| Product Name: | NSC 377363 | | Synonyms: | NSC 377363;Synucleozid;Synucleozid dihydrochloride;Synucleozid dihydrochloride 2-(4-((4-carbamimidoylphenyl)amino)phenyl)-1H-indole-6-carboximidamide;1H-Indole-6-carboximidamide, 2-[4-[[4-(aminoiminomethyl)phenyl]amino]phenyl]- | | CAS: | 502139-01-7 | | MF: | C22H20N6 | | MW: | 368.43 | | EINECS: | | | Product Categories: | | | Mol File: | 502139-01-7.mol |  |
| | NSC 377363 Chemical Properties |
| Boiling point | 649.7±65.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 16.11±0.30(Predicted) |
| | NSC 377363 Usage And Synthesis |
| Biological Activity | Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein (IC50=1.5 μM). Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson's disease[1]. | | References | [1]. Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467. |
| | NSC 377363 Preparation Products And Raw materials |
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