| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
17754423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:ICCB-19 HCl
CAS:1803605-68-6
Purity:98% HPLC LCMS Package:100MG;1G
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| | N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide hydrochloride Basic information |
| Product Name: | N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide hydrochloride | | Synonyms: | N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide hydrochloride;ICCB-19 hydrochloride;ICCB-19 HCl（750621-52-4 free base）;ICCB19,ubiquitination,cIAP2,TRADD,cIAP1,RDA,ICCB 19 hydrochloride,Receptor-interacting protein kinases,Autophagy,ICCB 19,beclin1,RIPK,RIP kinase,k63,Apoptosis,Inhibitor,RIPK1,ICCB19 hydrochloride,inhibit,ICCB-19 | | CAS: | 1803605-68-6 | | MF: | C12H22ClN3OS | | MW: | 291.84 | | EINECS: | | | Product Categories: | | | Mol File: | 1803605-68-6.mol |  |
| | N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide hydrochloride Chemical Properties |
| storage temp. | 4°C, protect from light | | solubility | DMSO : 83.33 mg/mL (285.53 mM; Need ultrasonic) | | form | Solid | | color | White to off-white |
| | N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide hydrochloride Usage And Synthesis |
| Biological Activity | ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins[1].
ICCB-19 inhibits Bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM[1]. ICCB-19 has no effect on mTOR. ICCB-19 (10 μM) treatment of cells increases the levels of DsRed-FYVE dots and the lipid kinase activity of VPS34[1]. ICCB-19 (10 μM) promotes autophagy via K63-linked ubiquitination of beclin 1 mediated by E3 ubiquitin ligases cIAP1 and cIAP2 and the adaptor TRAF2[1]. ICCB-19 (10 μM) reduces the rapid activation of RIPK1 in complex I induced by TNF. Treatment with ICCB-19 increases recruitment of TRADD, HOIP, and A20, but not RIPK1, to complex I[1].
ICCB-19 reduces inflammatory responses in Tradd-/- mice. ICCB-19 reduces expression of the TNF-induced inflammatory target gene products, NOS and COXII27, and of inflammatory cytokines in cells stimulated with pathogen-associated molecular patterns[1]. | | References | [1]. Daichao Xu, et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020 Nov;587(7832):133-138. |
| | N-cycloheptyl-2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)acetamide hydrochloride Preparation Products And Raw materials |
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