| 中文名称 | SSM 3 trifluoroacetate |
|---|---|
| 中文同义词 | |
| 英文名称 | SSM 3 trifluoroacetate |
| 英文同义词 | SSM3 tetraTFA |
| CAS号 | 2320930-10-5 |
| 分子式 | C24H33F3N12O4 |
| 分子量 | 610.6 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2320930-10-5.mol |
| 结构式 |  |
SSM 3 trifluoroacetate 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
EC50: 54 nM (furin)Ki: 12 nM (furin)
SSM3 tetraTFA is against furin cleavage of the Pyr-RTKR-AMC substrate with an EC 50 of 54 nM in vitro cleavage assays and cell-based tests.SSM3 tetraTFA (0.1-25 μM) inhibits the furin-dependent conversion of PA83 into PA63 in a dose dependent manner, it inhibits PA83 processing in the cleavage reactions.SSM3 tetraTFA shows comparable potency against furin (K i =0.012 μM) and PC6B (K i =0.004 μM), these compounds preferentially inhibited furin over PACE4 (K i =0.041 μM) by 2- to 10-fold and over PC7 (K i =0.595 μM) by 11- to 76-fold. In addition, it inhibits LF (K i =1.241 μM) 25- to 167-fold less effectively than in furin and shows no measurable inhibition against trypsin and MT1-MMP.