| Company Name: |
Adamas Reagent, Ltd.
|
| Tel: |
400-6009262 16621234537 |
| Email: |
chenyj@titansci.com |
| Products Intro: |
Product Name:4-Cyclopropyl-7-Fluoro-3,4-Dihydro-2H-Benzo[E][1,2,4]Thiadiazine 1,1-Dioxide
CAS:1204572-55-3
Purity:98% Package:100mg;250mg;1g
|
| Company Name: |
Dalian Meilun Biotech Co., Ltd.
|
| Tel: |
0411-62910999 13889544652 |
| Email: |
meilunui@163.com |
| Products Intro: |
Product Name:BPAM344
CAS:1204572-55-3
Purity:>98%,BR Package:5mg;10mg;25mg Remarks:MC8014
|
BPAM344 >=98% (HPLC) manufacturers
- BPAM344
-
- $50.00 / 5mg
-
2024-11-19
- CAS:1204572-55-3
- Min. Order:
- Purity: 99.53%
- Supply Ability: 10g
|
| | BPAM344 >=98% (HPLC) Basic information |
| Product Name: | BPAM344 >=98% (HPLC) | | Synonyms: | BPAM344 >=98% (HPLC);BPAM-344;Ionotropic glutamate receptors,GluK3a,PAM,iGluR,BPAM344,BPAM 344,Inhibitor,BPAM-344,KAR,GluK1b,GluK2a,inhibit;2H-1,2,4-Benzothiadiazine, 4-cyclopropyl-7-fluoro-3,4-dihydro-, 1,1-dioxide | | CAS: | 1204572-55-3 | | MF: | C10H11FN2O2S | | MW: | 242.27 | | EINECS: | | | Product Categories: | | | Mol File: | 1204572-55-3.mol |  |
| | BPAM344 >=98% (HPLC) Chemical Properties |
| Boiling point | 415.9±55.0 °C(Predicted) | | density | 1.504±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 250 mg/mL (1031.91 mM; Need ultrasonic) | | pka | 8.88±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | BPAM344 >=98% (HPLC) Usage And Synthesis |
| Biological Activity | BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM)[1].
BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics[1]. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold)[1]. | | References | [1]. Anja Probst Larsen, et al. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol Pharmacol. 2017 Jun;91(6):576-585. |
| | BPAM344 >=98% (HPLC) Preparation Products And Raw materials |
|