Company Name: |
TargetMol Chemicals Inc.
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4008200310 |
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marketing@tsbiochem.com |
Products Intro: |
Product Name:Glucocorticoid receptor agonist-1 CAS:2166375-82-0 Purity:99.51% Package:100 mg;50 mg;1 mg;5 mg;10 mg;25 mg;;
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| Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-[(3-aminophenyl)methyl]phenyl]methylene]bis(oxy)]-11,21-dihydroxy-, (11β,16α)- Basic information |
Product Name: | Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-[(3-aminophenyl)methyl]phenyl]methylene]bis(oxy)]-11,21-dihydroxy-, (11β,16α)- | Synonyms: | Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-[(3-aminophenyl)methyl]phenyl]methylene]bis(oxy)]-11,21-dihydroxy-, (11β,16α)-;Glucocorticoid receptor agonist-1;Glucocorticoid receptor agonist 1,Glucocorticoid receptor agonist1 | CAS: | 2166375-82-0 | MF: | C35H39NO6 | MW: | 569.7 | EINECS: | | Product Categories: | | Mol File: | 2166375-82-0.mol | ![Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-[(3-aminophenyl)methyl]phenyl]methylene]bis(oxy)]-11,21-dihydroxy-, (11β,16α)- Structure](CAS/20211123/GIF/2166375-82-0.gif) |
| Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-[(3-aminophenyl)methyl]phenyl]methylene]bis(oxy)]-11,21-dihydroxy-, (11β,16α)- Chemical Properties |
Boiling point | 778.5±60.0 °C(Predicted) | density | 1.34±0.1 g/cm3(Predicted) | storage temp. | 4°C, protect from light | form | Solid | pka | 12.87±0.10(Predicted) | color | White to off-white |
| Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-[(3-aminophenyl)methyl]phenyl]methylene]bis(oxy)]-11,21-dihydroxy-, (11β,16α)- Usage And Synthesis |
Biological Activity | Glucocorticoid receptor agonist-1 is a potent glucocorticoid receptor agonist with an IC50 of 2.8 nM extracted from patent WO2017210471A1, compound 41[1].
Glucocorticoid receptor agonist immunoconjugates are useful for treating autoimmune diseases such as, but not limited to, rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, adult Crohn’s disease, pediatric Crohn’s disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, uveitis, Behcets disease, a spondyloarthropathy, or psoriasis[1]. | References | [1]. Michael J. Mcpherson, et al. Glucocorticoid receptor agonist and immunoconjugates thereof. WO2017210471A1. |
| Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-[4-[(3-aminophenyl)methyl]phenyl]methylene]bis(oxy)]-11,21-dihydroxy-, (11β,16α)- Preparation Products And Raw materials |
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