methyl 2-[[(diethylamino)acetyl]amino]-3-methylbenzoate monohydrochloride

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Products Intro: Product Name:Benzoic acid,2-[[2-(diethylamino)acetyl]amino]-3-methyl-, methyl ester, hydrochloride (1:1)
CAS:7210-92-6
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Products Intro: Product Name:methyl 2-[[(diethylamino)acetyl]amino]-3-methylbenzoate monohydrochloride
CAS:7210-92-6
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Products Intro: Product Name:methyl 2-[[2-(diethylamino)acetyl]amino]-3-methylbenzoate,hydrochloride
CAS:7210-92-6
Purity:98% Package:25kg
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Products Intro: Product Name:Tolycaine Hydrochloride
CAS:7210-92-6
Company Name: United States Biological  
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Products Intro: Product Name:Tolycaine Hydrochloride
CAS:7210-92-6
methyl 2-[[(diethylamino)acetyl]amino]-3-methylbenzoate monohydrochloride Basic information
Product Name:methyl 2-[[(diethylamino)acetyl]amino]-3-methylbenzoate monohydrochloride
Synonyms:methyl 2-[[(diethylamino)acetyl]amino]-3-methylbenzoate monohydrochloride;Baycaine;Tolycaine hydrochloride;LIWOWASNSWUKPF-UHFFFAOYSA-N;methyl 2-[[2-(diethylamino)acetyl]amino]-3-methylbenzoate,hydrochloride;Benzoic acid,2-[[2-(diethylamino)acetyl]amino]-3-methyl-, methyl ester, hydrochloride (1:1)
CAS:7210-92-6
MF:C15H23ClN2O3
MW:314.80772
EINECS:2305907
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Mol File:7210-92-6.mol
methyl 2-[[(diethylamino)acetyl]amino]-3-methylbenzoate monohydrochloride Structure
methyl 2-[[(diethylamino)acetyl]amino]-3-methylbenzoate monohydrochloride Chemical Properties
Melting point 139-140.5°
storage temp. Hygroscopic, Refrigerator, under inert atmosphere
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Safety Information
MSDS Information
methyl 2-[[(diethylamino)acetyl]amino]-3-methylbenzoate monohydrochloride Usage And Synthesis
OriginatorTolycaine Hydrochloride,ZYF Pharm Chemical
UsesTolycaine Hydrochloride is an anesthetic drug.
DefinitionChEBI: Tolycaine hydrochloride is an amidobenzoic acid.
Manufacturing ProcessA suspension of 40 g 2-amino-3-methylbenzoic acid methyl ester in 125 ml of benzene was added 125 ml of saturated solution of sodium acetate and then at 0-5°C was added 37 g chloracetylchloride. The mixture was stirred for 1 hour at room temperature. The mixture was filtered. The organic layer was with 10% solution of potassium carbonate and dries under calcium chloride. By distillation of the mixture was obtained 15 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester; melting point 86-87.5°C (crystallization from a mixture acetic acid and ligroin); yield 21.8 g.
A mixture of 16 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester and 10 g diethyl amine in benzene was refluxed for 5 hours. After cooling the diethyl amine hydrochloride was deleted by filtration. The organic layer was washed with 2 N hydrochloric acid. To the solution was added potassium carbonate. The product was extracted with ether and distilled.
Therapeutic FunctionLocal anesthetic
methyl 2-[[(diethylamino)acetyl]amino]-3-methylbenzoate monohydrochloride Preparation Products And Raw materials
Raw materialsMethyl 2-amino-3-methylbenzoate-->Chloroacetyl chloride-->Diethylamine
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