异粒枝碱
| 中文名称 | 异粒枝碱 |
|---|---|
| 中文同义词 | 异粒枝碱;羟基箭毒碱;化合物 T11681 |
| 英文名称 | O7,O7'-didemethylcycleanine |
| 英文同义词 | O7,O7'-didemethylcycleanine;(+)-Isobebeerine;(1R,1'R)-2,2'-Dimethyl-6,6'-dimethoxy-7,18:11',18-diseco-8,18:12',18-dicyclotubocuraran-7,7'-diol;7-O,7'-O-Didemethylcycleanine;Isochondodendrine;(R,R)-Isochondodendrine;Cycleanine, o(sup 7),o(sup 7')-didemethyl-;Cycleanine, o7,o7'-didemethyl- (9ci) |
| CAS号 | 477-62-3 |
| 分子式 | C36H38N2O6 |
| 分子量 | 594.7 |
| EINECS号 | 2075172 |
| 相关类别 | |
| Mol文件 | 477-62-3.mol |
| 结构式 |  |
异粒枝碱 性质
| 熔点 | 316 °C (decomp) |
|---|---|
| 沸点 | 689.0±55.0 °C(Predicted) |
| 比旋光度 | D20 -29° (c = 1.3 in chloroform) |
| 密度 | 1.239±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 9.10±0.20(Predicted) |
Isochondrodendrine ( Isochondrodendrin) 是一类从 Isolona ghesquiereina 中分离出来的双苄基异喹啉生物碱。Isochondrodendrine 对 Plasmodium falciparum 具有很强的抗疟原虫活性。
Plasmodium falciparum
Isochondrodendrine has strong in vitro antiplasmodial activity against the chloroquine resistant strain FMC29 of Plasmodium falciparum . Toxicity observed is 50 to 100 fold greater towards Plasmodium falciparum than cultured L6 cells.
安全信息
| 毒性 | LD50 intraperitoneal in mouse: 1001mg/kg |
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