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UMB298

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UMB298 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:UMB298
CAS:2266569-73-5
Purity:99.76% Package:1mg;58USD|5mg;143USD|10mg;230USD
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:UMB298
CAS:2266569-73-5
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
Email:
Products Intro: Product Name:UMB298
CAS:2266569-73-5
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g
Company Name: ShangHai Biochempartner Co.,Ltd  
Tel: 177-54423994 17754423994
Email: 2853530910@QQ.com
Products Intro: Product Name:UMB298
CAS:2266569-73-5
Purity:98% HPLC LCMS Package:100MG;1G
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ:65489617 15618227136
Email: Sales@ATKchemical.com
Products Intro: Product Name:UMB298
CAS:2266569-73-5
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G

UMB298 manufacturers

  • UMB298
  • UMB298 pictures
  • $58.00 / 1mg
  • 2024-11-07
  • CAS:2266569-73-5
  • Min. Order:
  • Purity: 99.76%
  • Supply Ability: 10g
UMB298 Basic information
Product Name:UMB298
Synonyms:UMB298;UMB-298,UMB298,inhibit,MOLM13,Inhibitor,bromodomain,UMB 298,selective,potent,Epigenetic Reader Domain,CBP30;Imidazo[1,2-a]pyridin-3-amine, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-4-isoxazolyl)-;2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)imidazo[1,2-a]pyridin-3-amine
CAS:2266569-73-5
MF:C27H31ClN4O2
MW:479.01
EINECS:
Product Categories:
Mol File:2266569-73-5.mol
UMB298 Structure
UMB298 Chemical Properties
density 1.29±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 25 mg/mL (52.19 mM; Need ultrasonic)
pka7.87±0.50(Predicted)
Safety Information
MSDS Information
UMB298 Usage And Synthesis
Biological ActivityUMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1]. UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth[1].UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia[1].UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression[1].
References[1]. Muthengi A, et al. Development of Dimethylisoxazole-Attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors. J Med Chem. 2021;64(9):5787-5801.
UMB298 Preparation Products And Raw materials
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