Company Name: |
TargetMol Chemicals Inc.
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Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:NIK-250;NIK 250 CAS:1000817-20-8 Purity:98% Package:5 mg
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| 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1,4-dithiin-2-yl)-, 3,5-bis(4-pyridinylmethyl) ester Basic information |
Product Name: | 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1,4-dithiin-2-yl)-, 3,5-bis(4-pyridinylmethyl) ester | Synonyms: | 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1,4-dithiin-2-yl)-, 3,5-bis(4-pyridinylmethyl) ester | CAS: | 1000817-20-8 | MF: | C26H25N3O4S2 | MW: | 507.62 | EINECS: | | Product Categories: | | Mol File: | 1000817-20-8.mol | ![3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1,4-dithiin-2-yl)-, 3,5-bis(4-pyridinylmethyl) ester Structure](CAS/20210305/GIF/1000817-20-8.gif) |
| 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1,4-dithiin-2-yl)-, 3,5-bis(4-pyridinylmethyl) ester Chemical Properties |
Boiling point | 671.1±55.0 °C(Predicted) | density | 1.316±0.06 g/cm3(Predicted) | pka | 4.91±0.10(Predicted) |
| 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1,4-dithiin-2-yl)-, 3,5-bis(4-pyridinylmethyl) ester Usage And Synthesis |
Description | NIK-250 is a P-glycoprotein inhibitor. NIK250 might be useful in reversing MDR, which often develops during chemotherapy of advanced or hormone-resistant prostatic cancer. NIK250 could also reverse multidrug resistance in human glioma cells. The glioma cell lines were the two MRP-expressing cell lines, T98G and IN500, an MDR1-expressing cell line, CCF-STTG1, and the MRP1 MDR1-non-expressing cell line, IN157. |
| 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1,4-dithiin-2-yl)-, 3,5-bis(4-pyridinylmethyl) ester Preparation Products And Raw materials |
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