| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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sales@dcchemicals.com |
| Products Intro: |
Product Name:AC1-IN-38
CAS:2762422-55-7
Purity:98% HPLC Package:100mg，250mg，1g
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| | INDEX NAME NOT YET ASSIGNED Basic information |
| Product Name: | INDEX NAME NOT YET ASSIGNED | | Synonyms: | AC1-IN-1;Adenylyl cyclase,Adenylate Cyclase,Inhibitor,AC1IN1,Chronic Pain,inhibit,antiallodynic,nontoxic,HEK293 cells,AC1 IN 1,CNS-penetration;AC1-IN-38 | | CAS: | 2762422-55-7 | | MF: | C18H18FN5O2 | | MW: | 355.37 | | EINECS: | | | Product Categories: | | | Mol File: | 2762422-55-7.mol |  |
| | INDEX NAME NOT YET ASSIGNED Chemical Properties |
| density | 1.36±0.1 g/cm3(Predicted) | | pka | 7.00±0.50(Predicted) | | form | Solid | | color | White to off-white |
| | INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
| Biological Activity | AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 μM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity[1].
AC1-IN-1 (compound 38; HEK293 cells; 30 μM, 1 hours) shows nontoxic to this human cell line[1].
AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point[1]. | | References | [1]. Scott JA, et al. Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain. J Med Chem. 2022; 65(6):4667-4686. |
| | INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials |
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