Company Name: |
Zhengzhou Convergence Chemical Co. LTD
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Tel: |
0371-53736046 13393710386 |
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2853979814@qq.com |
Products Intro: |
Product Name:Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- CAS:2248703-42-4
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Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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Tel: |
0513-66337626 18051384581 |
Email: |
sales@chemhifuture.com |
Products Intro: |
Product Name:SACLAC CAS:2248703-42-4 Purity:98%+ HPLC Package:10mg,500mg,1g,2g,5g,10g,more
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Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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Tel: |
021-65675885 18964387627 |
Email: |
customer_service@efebio.com |
Products Intro: |
Product Name:SACLAC CAS:2248703-42-4 Purity:95% Package:1mg;5mg;10mg
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Company Name: |
Wuhan Acumen Bio-Technology Co.,ltd
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Tel: |
027-027-16602739303 16602739303 |
Email: |
673003916@qq.com |
Products Intro: |
Product Name:Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- CAS:2248703-42-4 Purity:95% HPLC Package:5G;1G
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
15002134094 |
Email: |
marketing@targetmol.cn |
Products Intro: |
Product Name:SACLAC; CAS:2248703-42-4 Purity:具体详见官网信息 Package:详见官网
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| Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Basic information |
| Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Chemical Properties |
Boiling point | 560.1±50.0 °C(Predicted) | density | 1.016±0.06 g/cm3(Predicted) | storage temp. | -20°C | solubility | Chloroform: soluble | form | A solid | pka | 13.01±0.46(Predicted) |
| Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Usage And Synthesis |
Biological Activity | SACLAC is an irreversible inhibitor of acid ceramidase (Ki = 97.1 nM) and a derivative of the acid ceramidase inhibitor SABRAC .1 It decreases levels of sphingosine-1-phosphate (S1P) and increases total ceramide levels in OCI-AML-2 acute myeloid leukemia (AML) cells when used at a concentration of 2.5 μM.2 SACLAC (10 and 20 μM) induces apoptosis in primary AML cells. It reduces leukemic burden in MV4-11 and U937 AML mouse xenograft models when administered at a dose of 5 mg/kg. | References | 1.Ordó?ez, Y.F., Abad, J.L., Aseeri, M., et al.Activity-based imaging of acid ceramidase in living cellsJ. Am. Chem. Soc.141(19)7736-7742(2019)
2.Pearson, J.M., Tan, S.-F., Sharma, A., et al.Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemiaMol. Cancer Res.18(3)352-363(2020) |
| Acetamide, 2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Preparation Products And Raw materials |
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