1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one manufacturers
- 5,6-Dihydrouridine
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- $35.00 / 1mg
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2024-11-19
- CAS:5627-05-4
- Min. Order:
- Purity: 99.57%
- Supply Ability: 10g
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| 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Basic information |
Product Name: | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one | Synonyms: | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one;Uridine, 5,6-dihydro-;Uridine Impurity 28(5,6-Dihydrouridine);6-Dihydrouridine;5,6-Dihydrouridine RNA-modified nucleoside D;dihydrouridine;1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione | CAS: | 5627-05-4 | MF: | C9H14N2O6 | MW: | 246.22 | EINECS: | | Product Categories: | | Mol File: | 5627-05-4.mol | |
| 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Chemical Properties |
density | 1.614±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMF: 16 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml | form | A crystalline solid | pka | 12.40±0.20(Predicted) | color | White to off-white | PH | ~11 | λmax | 208 (in H2O) | Stability: | Hygroscopic |
| 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Usage And Synthesis |
Uses | 5,6-Dihydrouridine is an intermediate used in the synthesis of 3,4,5,6-Tetrahydrouridine (>80%) (T310250), which is a derivative of Uridine (U829910). Tetrahydrouridine (THU) is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA. | Definition | ChEBI: The uridine derivative obtained by formal hydrogenation of the endocyclic double bond in the uracil ring. |
| 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Preparation Products And Raw materials |
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