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1-Piperidinecarboxylic acid, 3-[4-(carboxymethyl)-1H-pyrazol-1-yl]-, 1-(1,1-dimethylethyl) ester

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1-Piperidinecarboxylic acid, 3-[4-(carboxymethyl)-1H-pyrazol-1-yl]-, 1-(1,1-dimethylethyl) ester Suppliers list
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
Tel: 13504435624
Email: 1927928688@qq.com
Products Intro: Product Name:Rigid linker for PROTAC development
CAS:1781095-18-8
1-Piperidinecarboxylic acid, 3-[4-(carboxymethyl)-1H-pyrazol-1-yl]-, 1-(1,1-dimethylethyl) ester Basic information
Product Name:1-Piperidinecarboxylic acid, 3-[4-(carboxymethyl)-1H-pyrazol-1-yl]-, 1-(1,1-dimethylethyl) ester
Synonyms:1-Piperidinecarboxylic acid, 3-[4-(carboxymethyl)-1H-pyrazol-1-yl]-, 1-(1,1-dimethylethyl) ester
CAS:1781095-18-8
MF:C15H23N3O4
MW:309.36
EINECS:
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Mol File:1781095-18-8.mol
1-Piperidinecarboxylic acid, 3-[4-(carboxymethyl)-1H-pyrazol-1-yl]-, 1-(1,1-dimethylethyl) ester Structure
1-Piperidinecarboxylic acid, 3-[4-(carboxymethyl)-1H-pyrazol-1-yl]-, 1-(1,1-dimethylethyl) ester Chemical Properties
Boiling point 479.0±40.0 °C(Predicted)
density 1.26±0.1 g/cm3(Predicted)
pka4.15±0.10(Predicted)
Safety Information
MSDS Information
1-Piperidinecarboxylic acid, 3-[4-(carboxymethyl)-1H-pyrazol-1-yl]-, 1-(1,1-dimethylethyl) ester Usage And Synthesis
Uses2-(1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazol-4-yl)acetic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920533
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920703
reaction suitabilityreagent type: linker
1-Piperidinecarboxylic acid, 3-[4-(carboxymethyl)-1H-pyrazol-1-yl]-, 1-(1,1-dimethylethyl) ester Preparation Products And Raw materials
Tag:1-Piperidinecarboxylic acid, 3-[4-(carboxymethyl)-1H-pyrazol-1-yl]-, 1-(1,1-dimethylethyl) ester(1781095-18-8) Related Product Information