bimoclomol
中文名称 | bimoclomol |
---|---|
中文同义词 | 氯吡哌醇;化合物 T13580 |
英文名称 | bimoclomol |
英文同义词 | bimoclomol;3-Pyridinecarboximidoyl chloride, N-[2-hydroxy-3-(1-piperidinyl)propoxy]- |
CAS号 | 130493-03-7 |
分子式 | C14H20ClN3O2 |
分子量 | 297.78 |
EINECS号 | |
相关类别 | |
Mol文件 | 130493-03-7.mol |
结构式 | ![]() |
bimoclomol 性质
储存条件 | Store at -20°C |
---|---|
溶解度 | 溶于二甲基亚砜 |
形态 | 油状物 |
颜色 | 浅黄至棕色 |
HSP
|
Bimoclomol (40 μM) significantly increases coronary flow (CF) in the period of normoxic perfusion (before ischemia). Bimoclomol significantly increases LVDP and CO, but it decreases LVEDP under ischemic conditions. Bimoclomol displays a biphasic effect on the rate of relaxation. Bimoclomol (>10 μM) causes concentration-dependent vasorelaxation, with EC 50 value of 214 μM. Bimoclomol (100 μM) induces vasorelaxation also against 20 mM KCl. However, bimoclomol fails to relax preparations precontracted with serotonin, PGF2 or angiotensin II. Bimoclomol does not affect the stability of Hsp70 or its mRNA. Bimoclomol coinduces Hsp expression via the prolonged activation of the heat shock transcription factor (HSF-1). The effects of bimoclomol are abolished in cells from mice lacking HSF-1. Furthermore, bimoclomol can bind to HSF-1 and induce a prolonged binding of HSF-1 to the respective DNA elements. Bimoclomol (0.1, 1 and 10 μM) improves cell survival of rat neonatal cardiomyocytes compared to vehicle-treated cells. Bimoclomol (0.01 to 10 μM) significantly elevates HSP70 levels, based on the time of exposure. Pretreatment with bimoclomol for 24 h significantly increases survival of cells.
Bimoclomol (1 and 5 mg/kg) decreases the ST-segment elevation induced by coronary occlusion by 56% and 80%, respectively, in anesthetized dogs.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-U00398 | Bimoclomol | 1 mg | 2181元 | |
2024/04/30 | HY-U00398 | bimoclomol Bimoclomol | 130493-03-7 | 10mg | 8000元 |