AZ-1355
| 中文名称 | AZ-1355 |
|---|---|
| 中文同义词 | 化合物 T13563;化合物 AZ-1355 |
| 英文名称 | 11,12-dihydro-4-methoxydibenz(b,f)(1,4)oxazepine-8-carboxylate |
| 英文同义词 | 11,12-dihydro-4-methoxydibenz(b,f)(1,4)oxazepine-8-carboxylate;AZ-1355 (NSC 364889;Dibenz[b,f][1,4]oxazepine-8-carboxylic acid, 10,11-dihydro-4-methoxy-, ethyl ester;AZ1355,AZ 1355 |
| CAS号 | 75451-07-9 |
| 分子式 | C17H17NO4 |
| 分子量 | 299.32 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 75451-07-9.mol |
| 结构式 |  |
AZ-1355 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
AZ-1355 是一种有效的降脂药，并能够抑制体内血小板凝集，提高体外前列腺素 I2/血栓素A2 的比例。
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Prostaglandin I 2
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Thromboxane A 2
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AZ-1355 (50 mg/kg) significantly reduces serum TG and the 100 mg/kg dose results in serum TC and TG reduction in rat. AZ-1355 (100 mg/kg) reduces total liver TC in rats fed CE-2, and the 50 mg/kg dose reduces hepatic TC in rats fed the high fat diet on both bases, and it also reduces the total hepatic TG of the CE-2 fed rats. AZ-1355 (150 mg/kg) reproducibly lowers serum total cholesterol (TC) in the Triton hyperlipidemic mice.