| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Mps1-IN-5
CAS:2890819-31-3
Package:100mg/RMB 17500;25mg/RMB 10600;50mg/RMB 13800
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Mps1-IN-5 manufacturers
- Mps1-IN-5
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- $2500.00 / 100mg
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2024-11-19
- CAS:2890819-31-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Mps1-IN-5 Basic information |
| | Mps1-IN-5 Chemical Properties |
| | Mps1-IN-5 Usage And Synthesis |
| Uses | Mps1-IN-5 is a potent and orally active Mps1 inhibitor with an IC50 value of 29 nM. Mps1-IN-5 induces Apoptosis and cell cycle arrests at G2/M phase. Mps1-IN-5 shows antiproliferative activity and anti-tumor activity. Mps1-IN-5 inhibits phosphorylation of Mps1 and induces DNA damage[1]. | | in vivo | Mps1-IN-5 (30, 60 mg/kg; p.o.; daily for 15 days) inhibits tumor growth without obvious toxicity in breast cancer models[1]. | Animal Model: | 6-8 weeks, female BALB/C mice (4T1-luc mouse xenograft model)[1] | | Dosage: | 30, 60 mg/kg | | Administration: | P.o.; daily for 15 days | | Result: | Significantly suppressed tumor growth and caused negligible damage to organs such as heart, liver, spleen, lung and kidneys. |
| | References | [1] Li X, et al. Design, synthesis and biological evaluation of a new class of 7H-pyrrolo[2,3-d]pyrimidine derivatives as Mps1 inhibitors for the treatment of breast cancer. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114887. |
| | Mps1-IN-5 Preparation Products And Raw materials |
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