| Company Name: |
ChemStrong Scientific Co.,Ltd
|
| Tel: |
0755-0755-66853366 13670046396 |
| Email: |
sales@chem-strong.com |
| Products Intro: |
Product Name:Travoprost Impurity 21
CAS:1219032-18-4
Purity:95% HPLC Package:10mg;25mg;50mg;100mg
|
| Company Name: |
Hubei Yangxin Medical Technology Co., Ltd.
|
| Tel: |
15374522761 |
| Email: |
3003392093@qq.com |
| Products Intro: |
Product Name:Travoprost Impurity 16（9-keto Fluprostenol Isopropyl Ester）
CAS:1219032-18-4
Purity:95% HPLC Package:10mg;25mg;50mg;100mg
|
| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:9-keto Fluprostenol isopropyl ester
CAS:1219032-18-4
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
|
| | 9-keto Fluprostenol isopropyl ester Basic information |
| Product Name: | 9-keto Fluprostenol isopropyl ester | | Synonyms: | (+)-9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC-ACID, ISOPROPYL ESTER;9-KETO FLUPROSTENOL ISOPROPYL ESTER;FLUPROSTENOL PROSTAGLANDIN E2 ISOPROPYL ESTER;Travoprost Impurity 16（9-keto Fluprostenol Isopropyl Ester）;9-Keto Travoprost;Travoprost Impurity 35;Travoprost Impurity 21;Travoprost 12 | | CAS: | 1219032-18-4 | | MF: | C26H33F3O6 | | MW: | 498.53 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 9-keto Fluprostenol isopropyl ester Chemical Properties |
| Boiling point | 583.6±50.0 °C(Predicted) | | density | 1.241±0.06 g/cm3(Predicted) | | solubility | DMF: 30 mg/ml; DMF:PBS (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml | | pka | 13.32±0.20(Predicted) |
| | 9-keto Fluprostenol isopropyl ester Usage And Synthesis |
| Uses | 9-Keto Travoprost is an impurity of Travoprost (T715600), a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2). | | Uses | Fluprostenol is a well-studied, potent analog of prostaglandin F2α (PGF2α) and acts primarily through the FP receptor. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate. Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver and human platelet preparations. |
| | 9-keto Fluprostenol isopropyl ester Preparation Products And Raw materials |
|