ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2
| 中文名称 | ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2 |
|---|---|
| 中文同义词 | 化合物 T20481;拮抗剂G TFA盐;拮抗剂多肽ANTAGONIST G;P物质肽[ARG6, DTRP7, 9, N-(NME)PHE8]- SUBSTANCE P(6-11);拮抗剂G 三氟乙酸盐 |
| 英文名称 | (ARG6,D-TRP7,9,N-ME-PHE8)-SUBSTANCE P (6-11) |
| 英文同义词 | H-ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2;(ARG6,D-TRP7,9,N-ME-PHE8)-SUBSTANCE P (6-11);ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2;ANTAGONIST G;arginyl-tryptophyl-n-methylphenylalanyl-tryptophyl-leucyl-methioninamide;(arg6;Substance P, fragment 6-11, [Arg6, D-Trp7,9, NMePhe8];[Arg6, D-Trp7,9, N-Me-Phe8]-SubstanceP fragment6-11 |
| CAS号 | 115150-59-9 |
| 分子式 | C49H66N12O6S |
| 分子量 | 951.19 |
| EINECS号 | |
| 相关类别 | 标准品;Peptide |
| Mol文件 | 115150-59-9.mol |
| 结构式 |  |
ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2 性质
| RTECS号 | PC4360070 |
|---|---|
| 储存条件 | -15°C |
| 形态 | 固体 |
| 颜色 | 米白色至浅黄色 |
| 水溶解性 | Soluble to 1mg/ml in water |
Antagonist G 是有效的后叶加压素 (vasopressin) 的拮抗剂。Antagonist G 也是弱的 GRP 和缓激肽的弱拮抗剂。Antagonist G 可诱导 AG-1 的转录，是癌细胞对化疗增敏。
Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells.
Antagonist G activates JNK1 in SCLC cells.
Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%.
Cell Viability Assay
| Cell Line: | SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells. |
| Concentration: | 0-100 μM. |
| Incubation Time: | 24 h. |
| Result: | Inhibited cell growh. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-P1185 | ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2 Antagonist G | 115150-59-9 | 5mg | 1800元 |
| 2024/11/08 | HY-P1185 | Antagonist G | 10 mg | 2900元 |