| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Complement factor D
CAS:37213-56-2
Purity:90-110μg/mL PBS, pH 7.2, >= 90 % SDS-PAGE Package:10μg Remarks:C5688
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| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Email: |
info@creative-enzymes.com |
| Products Intro: |
Product Name:complement factor D
CAS:37213-56-2
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| | FACTOR D, HUMAN Basic information |
| | FACTOR D, HUMAN Chemical Properties |
| Hazard Codes | B | | WGK Germany | 3 |
| | FACTOR D, HUMAN Usage And Synthesis |
| Uses | Complement factor D is a serine protease essential for the activation of the alternative pathway in the complement system. Research of complement factor D has revealed that a self inhibitory loop is responsible for switch from a resting to active state. Additionally, recent research has linked a complement factor D gene, single nucleotide polymorphism (SNP) rs3826945, with age-related macular degeneration (AMD). In these AMD cases there was a significant increase in plasma complement factor D concentration, even though previous research has shown no association between complement factor D SNP genes and AMD. | | Biochem/physiol Actions | Complement factor D is a serine protease with structural homologies with chymotrypsin. In the complement cascade, factor D cleaves complement factor B in complex with activated complement component C3. It is identical to adipsin, which is expressed in adipose tissue. |
| | FACTOR D, HUMAN Preparation Products And Raw materials |
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