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Clearsynth Labs Limited
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+91-22-26355700 |
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info@clearsynth.com |
Products Intro: |
Product Name:(±)-Bupivacaine-d9 CAS:474668-57-0 Remarks:CS-C-01143
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Company Name: |
Nanjing Haolv Biotechnology Co.,Ltd
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025-84622273 17361806303 |
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3004208264@qq.com |
Products Intro: |
Product Name:(±)-Bupivacaine-d9 (butyl-d9) CAS:474668-57-0 Purity:98% Package:5g;25g;100g
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Company Name: |
TOSUN PHARM
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020-61855200 13326451905 |
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260366801@qq.com |
Products Intro: |
Product Name:Bupivacaine-d9 CAS:474668-57-0 Purity:98%以上 Package:10mg;50mg;100mg等多种规格 Remarks:REF-B04015
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| Bupivacaine-d9 Basic information |
Product Name: | Bupivacaine-d9 | Synonyms: | Bupivacaine-d9;rac-Bupivacaine-d9;Bupivacaine D9Q: What is
Bupivacaine D9 Q: What is the CAS Number of
Bupivacaine D9 Q: What is the storage condition of
Bupivacaine D9 Q: What are the applications of
Bupivacaine D9;2H9]-Bupivacaine;butyl-2H9]-(±)-Bupivacaine | CAS: | 474668-57-0 | MF: | C18H28N2O | MW: | 288.44 | EINECS: | | Product Categories: | | Mol File: | 474668-57-0.mol | |
| Bupivacaine-d9 Chemical Properties |
storage temp. | Store at -20°C | solubility | DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml | form | A solid |
| Bupivacaine-d9 Usage And Synthesis |
Uses | (±)-Bupivacaine-d9 (butyl-d9) is an internal standard, useful for the detection of corticosteroids in human plasma. | Biological Activity | Bupivacaine-d9 is intended for use as an internal standard for the quantification of bupivacaine by GC- or LC-MS. Bupivacaine is a sodium channel blocker and local anesthetic.1,2 It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM.3,4 Bupivacaine (10 μM) blocks cardiac sodium channels in a use-dependent manner and inhibits respiration in cardiac cell mitochondria when palmitoyl-carnitine or acetyl-carnitine are used as substrates (IC50s = 0.78 and 0.37 mM, respectively).1,5 It also reduces thermal hyperplasia in a rat model of sciatic ligation injury when 0.6 ml of a 0.5% solution is administered into the perinerve space, and the duration of this effect is extended by co-administration of the NMDA receptor antagonist MK-801 .2 Formulations containing bupivacaine have been used as local anesthetics for surgery, oral surgery, and dental procedures and for anesthetic purposes in research studies using animals. | References | 1.Arlock, P.Actions of three local anaesthetics: lidocaine, bupivacaine and ropivacaine on guinea pig papillary muscle sodium channels (Vmax)Pharmacol. Toxicol.63(2)96-104(1988)
2.Mao, J., Price, D.D., Mayer, D.J., et al.Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathyBrain Res.576(2)254-262(1992)
3.Olschewski, A., Hempelmann, G., Vogel, W., et al.Blockade of Na+ and K+ currents by local anesthetics in the dorsal horn neurons of the spinal cordAnesthesiology88(1)172-179(1998)
4.Tabatabai, M., and Booth, A.M.Mechanism of action of local anesthetics on synaptic transmission in the ratAnesth. Analg.71(2)149-157(1990)
5.Weinberg, G.L., Palmer, J.W., VadeBoncouer, T.R., et al.Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondriaAnesthesiology92(2)523-528(2000) |
| Bupivacaine-d9 Preparation Products And Raw materials |
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