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Dextroamphetamine phosphate

Dextroamphetamine phosphate Basic information
Product Name:Dextroamphetamine phosphate
Synonyms:Dextroamphetamine phosphate;Dextroamphetamine phosphate [usp xx]
CAS:7528-00-9
MF:C9H16NO4P
MW:233.201401
EINECS:
Product Categories:
Mol File:7528-00-9.mol
Dextroamphetamine phosphate Structure
Dextroamphetamine phosphate Chemical Properties
Safety Information
MSDS Information
Dextroamphetamine phosphate Usage And Synthesis
General DescriptionDextroamphetamine, (+)-(S)-methylphenethylamine, formssalts with sulfuric acid (Dexedrine) and with phosphoric acids.The phosphate is the more water-soluble salt and is preferredif parenteral administration is required. The dextrorotatoryisomer has the (S) configuration and fewer cardiovascular effectsthan the levorotatory (R)-isomer. Additionally, it may beup to 10 times as potent as the (R)-isomer as an alerting agentand about twice as potent a psychotomimetic agent. Althoughit is a more potent psychotomimetic agent than the (R)-isomer,it has a better ratio of alerting to psychotomimetic effects.
The major mode of action of dextroamphetamine is releaseof NE from the mobile pool of the nerve terminal. Othermechanisms, such as inhibition of uptake, may make a smallcontribution to the overall effects. The alerting actions relateto increased NE available to interact with postsynaptic receptors(α1). Central β-receptor activation has classically beenconsidered the basis for most of the anorexiant effect.
Clinical UseDextroamphetamine phosphate is a strongly basic amine, with valuesfrom 9.77 to 9.94 reported. Absorption from the gastrointestinaltract occurs as the lipid-soluble amine. The drug is not extensively protein bound. Varying amounts ofthe drug are excreted intact under ordinary conditions.
Dextroamphetamine phosphate Preparation Products And Raw materials
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