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PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES)

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Company Name: Riedel-de Haen AG  
Tel: 800 558-9160
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Products Intro: Purity:95% (PAGE)
Company Name: SIGMA-RBI  
Tel: 800 736 3690 (Orders)
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PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES) Basic information
Product Name:PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES)
Synonyms:PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES);PR3 Ag;Proteinase3 from human leukocytes
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MW:0
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Mol File:Mol File
PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES) Structure
PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES) Chemical Properties
storage temp. −20°C
Safety Information
Hazard Codes B
WGK Germany 3
MSDS Information
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SigmaAldrich English
PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES) Usage And Synthesis
UsesProteinase 3 has been shown to be important in the pathogenesis of human emphysema. It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.
General DescriptionProteinase 3 (PR3) is mapped to human chromosome 19p13.3. Proteinase 3 is present majorly in azurophilic granules and belongs to neutrophil-derived proteases family. PR3 is a peripheral membrane protein and lacks transmembrane domain. It comprises of an unique interfacial binding site (IBS) and two amino acid clusters, one charged and one hydrophobic, for membrane association.
Biochem/physiol ActionsProteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.
PROTEINASE 3 HUMAN PR3 AG (DONOR LEUKOCYTES) Preparation Products And Raw materials
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