Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Tel: |
18818260767 |
Email: |
sales@chemegen.com |
Products Intro: |
Product Name:CAY10597 CAS:916046-55-4 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:CAY10597 CAS:916046-55-4 Package:10mg/RMB 9690;1mg/RMB 1240;5mg/RMB 5470
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CAY10597 manufacturers
- CAY10597
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- $1380.00 / 10mg
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2024-10-24
- CAS:916046-55-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| CAY10597 Basic information |
Product Name: | CAY10597 | Synonyms: | 5-CHLORO-1'-[(2-FLUOROPHENYL)METHYL]-2,2',5'-TRIOXO-SPIRO[3H-INDOLE-3,3'-PYRROLIDINE-1(2H)-ACETIC ACID];CAY10597;2-(5-chloro-1'-(2-fluorobenzyl)-2,2',5'-trioxospiro[indoline-3,3'-pyrrolidin]-1-yl)acetic acid;Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(2-fluorophenyl)methyl]-2,2',5'-trioxo- | CAS: | 916046-55-4 | MF: | C20H14ClFN2O5 | MW: | 416.79 | EINECS: | | Product Categories: | | Mol File: | 916046-55-4.mol | |
| CAY10597 Chemical Properties |
storage temp. | Store at -20°C | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.30 mg/ml | form | A crystalline solid |
| CAY10597 Usage And Synthesis |
Description | The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the human and murine CRTH2/DP2 receptor, respectively. The R enantiomer of CAY10597 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-prostaglandin D2 with an IC50 value of 40 nM. |
| CAY10597 Preparation Products And Raw materials |
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