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Triethylene Glycol 2-Bromoethyl Methyl Ether

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Company Name: 9i LLC
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Products Intro: Product Name:13-Bromo-2,5,8,11-tetraoxatridecane
CAS:110429-45-3
Purity:min.95% Package:225USD/1 g Remarks:NA29
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Products Intro: Product Name:Triethylene Glycol 2-Bromoethyl Methyl Ether
CAS:110429-45-3
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Products Intro: Product Name:Triethylene Glycol 2-Bromoethyl Methyl Ether
CAS:110429-45-3
Purity:99% Package:1KG;1USD
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
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Products Intro: Product Name:Bromo-PEG4-methoxy
CAS:110429-45-3
Purity:98% Package:Package as requetsed
Company Name: Zhengzhou Alfa Chemical Co.,Ltd
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Products Intro: CAS:110429-45-3
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Triethylene Glycol 2-Bromoethyl Methyl Ether manufacturers

  • m-PEG4-Br
  • m-PEG4-Br pictures
  • $0.00 / 100mg
  • 2024-10-24
  • CAS:110429-45-3
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
  • m-PEG4-Br
  • m-PEG4-Br pictures
  • $0.00 / 25g
  • 2024-03-27
  • CAS:110429-45-3
  • Min. Order: 25g
  • Purity: >98.00%
  • Supply Ability: 25g
Triethylene Glycol 2-Bromoethyl Methyl Ether Basic information
Product Name:Triethylene Glycol 2-Bromoethyl Methyl Ether
Synonyms:Triethylene Glycol 2-Bromoethyl Methyl Ether;m-PEG4-bromide;Methyl-PEG4-bromide;2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide 1-Bromo-3,6,9,12-tetraoxatridecane;Bromo-PEG4-methoxy;13-Bromo-2,5,8,11-tetraoxatridecane;mPEG4-Br;2,5,8,11-Tetraoxatridecane, 13-bromo-
CAS:110429-45-3
MF:C9H19BrO4
MW:271.15
EINECS:
Product Categories:
Mol File:110429-45-3.mol
Triethylene Glycol 2-Bromoethyl Methyl Ether Structure
Triethylene Glycol 2-Bromoethyl Methyl Ether Chemical Properties
Boiling point 296.3±25.0 °C(Predicted)
density 1.256±0.06 g/cm3(Predicted)
refractive index 1.4620 to 1.4660
storage temp. 2-8°C
form clear liquid
color White to Yellow to Green
CAS DataBase Reference110429-45-3
Safety Information
HS Code 2909.19.6000
MSDS Information
Triethylene Glycol 2-Bromoethyl Methyl Ether Usage And Synthesis
Descriptionm-PEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
Biological ActivityTriethylene Glycol 2-Bromoethyl Methyl Ether is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs) of trastuzumab (HY-P9907). It was placed distal to the monomethyl auristatin E (MMAE) payload to generate ADCs with altered hydrophilicity, antigen binding and in vitro potency. Tetraethylene glycol monotosylate can also be used as a linker of PROTAC, which can be used for the synthesis of PROTAC.
in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Triethylene Glycol 2-Bromoethyl Methyl Ether Preparation Products And Raw materials
Tag:Triethylene Glycol 2-Bromoethyl Methyl Ether(110429-45-3) Related Product Information
Phosphorus oxybromide m-PEG4-aldehyde mPEG3-CH2COOH Triethylene Glycol Mono(2-propynyl) Ether 1-{2-[2-(2-{2-[2-(2-Bromo-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-2-methoxy-ethane mPEG12-Br m-PEG5-bromide Bromo-PEG3-Acid 25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane m-PEG9-bromide NONAETHYLENE GLYCOL MONOMETHYL ETHER Methyl-PEG12-bromide MPEG3-CH2CH2COOH 2,5,8,11,14-pentaoxahexadecan-16-oic acid 2,5,8,11,14,17,20-Heptaoxadocosan-22-amine Methyl-PEG10-azide Methyl-PEG9-bromide m-PEG6-bromide