(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide

(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:SU1498
CAS:168835-82-3
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Su1498
CAS:168835-82-3
Purity:99.54% Package:1mg;34USD|2mg;47USD|5mg;72USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:SU-1498
CAS:168835-82-3
Purity:98% Package:5mg Remarks:V15393
Company Name: TargetMol Chemicals Inc.
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Email: support@targetmol.com
Products Intro: Product Name:Su1498;AG 1498;Tyrphostin SU 1498
CAS:168835-82-3
Package:10 mg;2 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel: 13417589054
Email: trendseenbio@gmail.com
Products Intro: Product Name:(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
CAS:168835-82-3
Purity:99% Package:1kg;25kg

(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide manufacturers

  • Su1498
  • Su1498 pictures
  • $34.00 / 1mg
  • 2024-11-19
  • CAS:168835-82-3
  • Min. Order:
  • Purity: 99.54%
  • Supply Ability: 10g
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Basic information
Product Name:(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
Synonyms:(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide;(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropy;SU1498, >98%;Tyrphostin SU 1498, >98%;CS-1481;(E)-2-CYANO-3-(4-HYDROXY-3;5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE;CHEMBL261508
CAS:168835-82-3
MF:C25H30N2O2
MW:390.52
EINECS:
Product Categories:
Mol File:168835-82-3.mol
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Structure
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Chemical Properties
Melting point 126 °C
Boiling point 590.6±50.0 °C(Predicted)
density 1.100±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO.
pka10.30±0.36(Predicted)
form powder
color white to beige
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
CAS DataBase Reference168835-82-3
Safety Information
HS Code 2926.90.4801
MSDS Information
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Usage And Synthesis
DescriptionSU-1498 (168835-82-3) is a potent, reversible, selective inhibitor of VEGFR-2, also known as Flk-1 (IC50 = 700 nM). Inhibition of VEGFR-2 blocks angiogenesis in both in vitro and in vivo models. Cell permeable.
UsesSU 1498 is an inhibitor of VEGF receptor kinase.
DefinitionChEBI: SU1498 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enoic acid with the amino group of 3-phenylpropylamine. It has a role as a vascular endothelial growth factor receptor antagonist. It is an enamide, a member of phenols, a nitrile, a monocarboxylic acid amide and a secondary carboxamide.
Biochem/physiol ActionsSU1498 is a potent and selective inhibitor of the VEGFR2 receptor kinase, Flk-1 with an IC50 value of 700 nM. SU1498 is a very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase with IC50 values > 50 μM. SU1498 has been used to study the role of VEGFR2 (Flk-1) in a variety of biological activities including angiogenesis, tumor growth inhibition, and stem cell proliferation.
References1) Cho et al. (2005), Retinoic acid and erythropoietin maintain alveolar development in mice treated with an angiogenesis inhibitor; Am. J. Respir. Cell Mol. Biol., 33 622 2) Wang et al. (2002), Interplay between integrins and FLK-1 in shear stress-induced signaling; Am. J. Physiol. Cell Physiol., 283 C1540 3) Strawn et al. (1996), FLK-1 as a target for tumor growth inhibition; Cancer Res., 56 3540
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Preparation Products And Raw materials
Tag:(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide(168835-82-3) Related Product Information
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