诺美林草酸盐 CAS#: 141064-23-5

诺美林草酸盐

生物活性靶点体外研究体内研究用途与合成方法 MSDS 诺美林草酸盐价格(试剂级) 上下游产品信息

中文名称	诺美林草酸盐
中文同义词	诺美林草酸盐;草酸占诺美林;呫诺美林草酸盐;化合物 T13353;占诺美林草酸盐;XANOMELINE OXALATE 诺美林草酸盐
英文名称	3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate
英文同义词	3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine ethanedioate (1:1);3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate;Xanomeline oxalate;3-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine oxalate;Lumeron;LY246708;MEMCOR;LUMERON;LY246708 oxalate;Xanomeline oxalate salt
CAS号	141064-23-5
分子式	C14H23N3OS.C2H2O4
分子量	371
EINECS号
相关类别	1
Mol文件	141064-23-5.mol
结构式

诺美林草酸盐性质

熔点	148-150℃
储存条件	Desiccate at +4°C
溶解度	DMF：1.6mg/mL； DMF:PBS (pH 7.2) (1:9)：0.1 mg/mL
形态	粉末
颜色	白色至米白色

诺美林草酸盐用途与合成方法

生物活性

Xanomeline oxalate (LY246708 oxalate) 是一种有效的、选择性毒蕈碱受体激动剂 (SMRA)，可刺激体内的磷酸肌醇水解。 Xanomeline oxalate 可用于研究阿尔茨海默氏病。

靶点

muscarinic receptor

体外研究

Xanomeline stimulates phosphoinositide (PI) hydrolysis in the A9 L m1 cells.
Xanomeline inhibits [ ³ H]-pirenzepine ([ ³ H]-PZ) and [ ³ H]- oxotremorine -M ([ ³ H]-OXO-M) binding to rat brain with K _i s of 7 and 3 nM, respectively.

体内研究

Xanomeline robustly stimulates in vivo PI hydrolysis and the effect is blocked by muscarinic antagonists, demonstrating mediation by muscarinic receptors. In mice the ED ₁₀₀ for Xanomeline-induced stimulation of [ ³ H]-IP accumulation is 54 μmole/kg in hippocampus. And in rats the ED ₁₀₀ for Xanomeline-induced stimulation of [ ³ H]-IP accumulation is 8.1 μmole/kg in hippocampus.

Animal Model:	Male CF1 mice weighing 18-20 g are injected [ ³ H]-myoinositol
Dosage:	8.1-81 μmole/kg
Administration:	S.c. injections; 1 h prior to killing and 1 h after the administration
Result:	Increased accumulation in a dose-related manner up to 130%, 75%, 60% above lithium levels in hippocampus, cortex and neostriatum, respectively. And did not increase accumulation of [ ³ H]-IP in the brain stem. Induced salivation, tremor and hypothermia in mice with the ED ₅₀ of 13.7±0.8 μmole/kg.

Animal Model:	Rats are injected [ ³ H]-myoinositol
Dosage:	2.7-81 μmole/kg
Administration:	S.c. injections; 1 h prior to killing and 1 h after the administration
Result:	Increased [ ³ H]-IP formation dose dependently in hippocampus up to 221% above lithium control.

安全信息

MSDS信息

诺美林草酸盐价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-13410	Xanomeline oxalate		1 mg	290元
2024/04/30	HY-13410	诺美林草酸盐 Xanomeline oxalate	141064-23-5	10mM * 1mLin DMSO	770元

诺美林草酸盐