5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
中文名称 | 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime |
---|---|
中文同义词 | 5'-氟-3-(肟基)-[2,3'-双吲哚亚基]-2'-酮;化合物5'-FLUOROINDIRUBINOXIME;5'-氟二异丁酮肟;5'-氟二异丁酮肟;5'-氟-3-(肟基)-[2,3'-双吲哚亚基]-2'-酮 |
英文名称 | 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime |
英文同义词 | 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime;5'-Fluoroindirubinoxime;-Fluoroindirubinoxime;5'-FIO;2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-5-fluoro-1,3-dihydro-;FLT3,HT-1080,CD135,A549,Cluster of differentiation antigen 135,RK3E-ras,SNU-638,Fms like tyrosine kinase 3,Inhibitor,5'Fluoroindirubinoxime,inhibit,5' Fluoroindirubinoxime,5'-Fluoroindirubinoxime;PD 082106;5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime |
CAS号 | 861214-33-7 |
分子式 | C16H10FN3O2 |
分子量 | 295.27 |
EINECS号 | |
相关类别 | 标准品 |
Mol文件 | 861214-33-7.mol |
结构式 | ![]() |
5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 性质
沸点 | 528.3±50.0 °C(Predicted) |
---|---|
密度 | 1.57±0.1 g/cm3(Predicted) |
储存条件 | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
溶解度 | DMSO:83.33 mg/mL(282.22 mM;需要超声波) |
形态 | 粉末 |
酸度系数(pKa) | 8.48±0.20(Predicted) |
颜色 | 浅棕色至黑色 |
15 nM (FLT3).
5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC
50
values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively.
5'-Fluoroindirubinoxime (5’-FIO) exhibits IC
50
values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells.
5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats.
Animal Model: | Rat tumor model based RK3E-ras cells. |
Dosage: | S.C.. |
Administration: | 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6. |
Result: | Effectively inhibited tumor growth. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-103464 | 5'-Fluoroindirubinoxime | 5 mg | 1600元 | |
2024/08/19 | HY-103464 | 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 5'-Fluoroindirubinoxime | 861214-33-7 | 10mM * 1mLin DMSO | 1760元 |