5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime CAS#: 861214-33-7

5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime

生物活性靶点体外研究体内研究用途与合成方法 MSDS 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime价格(试剂级) 上下游产品信息

中文名称	5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
中文同义词	5'-氟-3-(肟基)-[2,3'-双吲哚亚基]-2'-酮;化合物5'-FLUOROINDIRUBINOXIME;5'-氟二异丁酮肟;5'-氟二异丁酮肟;5'-氟-3-(肟基)-[2,3'-双吲哚亚基]-2'-酮
英文名称	5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
英文同义词	5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime;5'-Fluoroindirubinoxime;-Fluoroindirubinoxime;5'-FIO;2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-5-fluoro-1,3-dihydro-;FLT3,HT-1080,CD135,A549,Cluster of differentiation antigen 135,RK3E-ras,SNU-638,Fms like tyrosine kinase 3,Inhibitor,5'Fluoroindirubinoxime,inhibit,5' Fluoroindirubinoxime,5'-Fluoroindirubinoxime;PD 082106;5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
CAS号	861214-33-7
分子式	C16H10FN3O2
分子量	295.27
EINECS号
相关类别	标准品
Mol文件	861214-33-7.mol
结构式

5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 性质

沸点	528.3±50.0 °C(Predicted)
密度	1.57±0.1 g/cm3(Predicted)
储存条件	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度	DMSO：83.33 mg/mL（282.22 mM；需要超声波）
形态	粉末
酸度系数(pKa)	8.48±0.20(Predicted)
颜色	浅棕色至黑色

5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 用途与合成方法

生物活性

5'-Fluoroindirubinoxime (compound 13) 是Indirubin (HY-N0117) 的衍生物，是FLT3 的抑制剂，其IC50 值为15 nM。

靶点

15 nM (FLT3).

体外研究

5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC ₅₀ values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively.
5'-Fluoroindirubinoxime (5’-FIO) exhibits IC ₅₀ values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells.

体内研究

5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats.

Animal Model:	Rat tumor model based RK3E-ras cells.
Dosage:	S.C..
Administration:	10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6.
Result:	Effectively inhibited tumor growth.

安全信息

MSDS信息

5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2024/08/19	HY-103464	5'-Fluoroindirubinoxime		5 mg	1600元
2024/08/19	HY-103464	5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime 5'-Fluoroindirubinoxime	861214-33-7	10mM * 1mLin DMSO	1760元

5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime