R-雌马酚
中文名称 | R-雌马酚 |
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中文同义词 | R-雌马酚;ERΑ和ERΒ激动剂((R)-EQUOL);(R)-3-(4-羟基苯基)四氢苯并吡喃-7-醇;(+)-交牌;(R)-EQUOL化学试剂 |
英文名称 | R-Equol |
英文同义词 | (R)-Equol,99%e.e.;R-Equol;(3R)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol;(R)-Equol Exclusive;Isoequol;(R)-Equol,(R) Equol,(R)Equol,Inhibitor,Estrogen Receptor/ERR,inhibit;2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-, (3R)- |
CAS号 | 221054-79-1 |
分子式 | C15H14O3 |
分子量 | 242.27 |
EINECS号 | |
相关类别 | 细胞生物学试剂 |
Mol文件 | 221054-79-1.mol |
结构式 |
R-雌马酚 性质
熔点 | 184-187 °C |
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沸点 | 441.7±45.0 °C(Predicted) |
密度 | 1.286±0.06 g/cm3(Predicted) |
溶解度 | DMF:10mg/mL; DMSO:20mg/mL;乙醇:20mg/mL;乙醇:PBS (pH 7.2) (1:10): 0.1 mg/mL |
形态 | 结晶固体 |
酸度系数(pKa) | 9.94±0.40(Predicted) |
颜色 | 白色至黄色 |
Ki: 27.4 nM (ERα), 15.4 nM (ERβ)
(R)-Equol is an agonist of both ERα and ERβ with K i s of 27.4 and 15.4 nM, respectively. (R)-Equol induces a dose-dependent inhibitory effect on the invasive capacity of MDA-MB-231 cells that is significant at the highest concentration tested (50 μM). Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035).
Animals fed (R)-Equol have a significantly reduced number of palpable tumors over time when compare with Controls (P=0.002). Furthermore, the number of palpable tumors formed per rat in the (R)-Equol-fed group is significantly lower than that of rats treated with S-(-)equol (P=0.008). (R)-Equol-fed animals have 43% fewer tumors than the control group and this difference is highly statistically significant (P=0.004). The number of tumors/tumor-bearing animal is significantly lower in the animals fed (R)-Equol compare with Controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) when compare with Controls (9.9±1.4 mg). Feeding the (R)-Equol diet results in significantly increased tumor latency (P=0.003).
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-108414 | R-雌马酚 (R)-Equol | 221054-79-1 | 5mg | 770元 |
2024/08/19 | HY-108414 | R-雌马酚 (R)-Equol | 221054-79-1 | 10mM * 1mLin DMSO | 847元 |