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| 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide Basic information |
Product Name: | 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide | Synonyms: | 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide;PF 429242;o)Meth (2-MetR)-4-((diethylaMinyl)-Nhoxyphenethyl)-N-(pyrrolidin-3-yl)benzaMide;4-((diethylaMino)Methyl)-N-(2-Methoxyphenethyl)-N-(pyrrolidin-3-yl)benzaMide;PF-429242 dihydrochloride;4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinyl-benzamide dihydrochloride;Benzamide, 4-[(diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinyl-;-4-((Diethylamino) | CAS: | 947303-87-9 | MF: | C25H35N3O2 | MW: | 409.57 | EINECS: | | Product Categories: | | Mol File: | 947303-87-9.mol | |
| 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide Chemical Properties |
Boiling point | 562.2±50.0 °C(Predicted) | density | 1.11±0.1 g/cm3(Predicted) | storage temp. | Sealed in dry,2-8°C | solubility | H2O: soluble15mg/mL, clear | form | powder | pka | 9.47±0.10(Predicted) | color | white to beige | InChIKey | XKPJTOHUPQWSOJ-HSZRJFAPSA-N |
Hazard Codes | Xi,N | Risk Statements | 36/37/38-50 | Safety Statements | 26-61 | RIDADR | UN 3077 9 / PGIII | WGK Germany | 3 |
| 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide Usage And Synthesis |
Uses | PF 429242 is a novel subtilisin kexin isozyme-1/site-1 (SKI-1/S1P) protease inhibitor. PF 429242 is a sterol regulatory element-binding protein1 (SREBP1) inhibitor and has been shown to decrease pancreatic cancer cell viability and proliferation. | Biochem/physiol Actions | PF-429242 is a potent inhibitor of S1P (cellular proprotein convertase sterol regulatory element-binding protein (SREBP) site 1 protease) that reduces expression levels of hepatic SREBP target genes and lower rates of cholesterol and fatty acid synthesis in mice. PF-429242 is a potent antiviral agent against prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV in cultured cells. PF-429242 efficiently prevented the processing of GPC from the LCMV and LASV. PF-429242 is expected to be active against CCHFV. |
| 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide Preparation Products And Raw materials |
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