7-脱氮-2'-C-乙炔腺苷
中文名称 | 7-脱氮-2'-C-乙炔腺苷 |
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中文同义词 | 7-脱氮-2'-C-乙炔腺苷;化合物 T16325;2'-C-乙炔基杀结核菌素;2'-C-乙炔基杀结核菌素 |
英文名称 | 7-Deaza-2'-C-ethynyladenosine |
英文同义词 | 7-Deaza-2'-C-ethynyladenosine;(2R,3R,4R,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;7-Deaza-2'-C-acetylene-adenosine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-C-ethynyl-β-D-ribofuranosyl)-;7-(2-C-Ethynyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;NITD008;NITD008,NITD-008;2’-b-C-Ethynyl?tubercidin |
CAS号 | 1044589-82-3 |
分子式 | C13H14N4O4 |
分子量 | 290.28 |
EINECS号 | |
相关类别 | |
Mol文件 | 1044589-82-3.mol |
结构式 | ![]() |
7-脱氮-2'-C-乙炔腺苷 性质
沸点 | 631.8±55.0 °C(Predicted) |
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密度 | 1?+-.0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
酸度系数(pKa) | 10.48±0.70(Predicted) |
颜色 | 白色至灰色 |
EC50: 0.64 μM ( DENV-2 )
NITD008 potently inhibits other, including Dengue virus (DENV), West Nile virus, yellow fever virus, and Poissan virus. NITD008 inhibits DENV-2 in a dose-responsive manner, with an EC 50 value of 0.64 μM; treatment with 9 μM compound reduces viral titer by >104-fold. NITD008 also inhibits a luciferase-reporting replicon of hepatitis C virus (HCV, genotype 1b), a member from the genus Hepacivirus, with an EC 50 value of 0.11 μM.
NITD008 is orally bioavailable and has good pharmacokinetic properties. NITD008 exhibits the best pharmacokinetic parameters when formulated using 6 N of HCl (1.5 equimolar amount), 1 N of NaOH (pH adjusted to 3.5), and 100 mM citrate buffer (pH 3.5). Following i.v. injection, NITD008 has a high volume of distribution (3.71 L/kg) and a low systemic clearance (31.11 mL/min per kg), resulting in a long elimination half-life (t 1/2 =4.99 h). After p.o. dosing, NITD008 is rapidly absorbed (time of peak plasma concentration=0.5 h), with a maximal plasma concentration of 3 μM and bioavailability of 48%. Treatment of the mice immediately after viral infection with 1 mg/kg of NITD008 does not reduce mortality, but treatment with 3 mg/kg partially protects and treatment with ≥10 mg/kg completely protects the infected mice from death. NITD008 can suppress peak viremia, decrease cytokine elevation, and prevent death.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-12957 | 7-脱氮-2'-C-乙炔腺苷 NITD008 | 1044589-82-3 | 1mg | 1591元 |
2024/08/19 | HY-12957 | 7-脱氮-2'-C-乙炔腺苷 NITD008 | 1044589-82-3 | 5mg | 3500元 |