- SEA0400
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- $33.00 / 1mg
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2024-11-19
- CAS:223104-29-8
- Min. Order:
- Purity: 99.29%
- Supply Ability: 10g
- SEA-0400
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- $1.00 / 1KG
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2019-08-08
- CAS:223104-29-8
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 100KG
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| | SEA-0400 Basic information |
| Product Name: | SEA-0400 | | Synonyms: | SEA-0400;BenzenaMine, 2-[4-[(2,5-difluorophenyl)Methoxy]phenoxy]-5-ethoxy-;2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine;2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline;2-(4-((2,5-DIFLUOROBENZYL)OXY)PHENOXY)-5-ETHOXYANILINE;SEA 0400; SEA-0400;CS-1043;SEA 0400; SEA-0400;SEA0400 | | CAS: | 223104-29-8 | | MF: | C21H19F2NO3 | | MW: | 371.38 | | EINECS: | | | Product Categories: | | | Mol File: | 223104-29-8.mol |  |
| | SEA-0400 Chemical Properties |
| Boiling point | 485.0±45.0 °C(Predicted) | | density | 1.254±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | insoluble in H2O; ≥18.57 mg/mL in DMSO; ≥46.4 mg/mL in EtOH with ultrasonic | | form | solid | | pka | 4.04±0.10(Predicted) | | color | White to khaki |
| | SEA-0400 Usage And Synthesis |
| Description | SEA0400 is a selective inhibitor of the Na+/Ca2+ exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively). It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson''s disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models. | | Uses | SEA 0400 is a novel and selective inhibitor of Na+-Ca2+ exchanger. | | in vivo | SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats[1]. SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice[3]. | | target | Na+-Ca2+ exchanger | | storage | Store at -20°C |
| | SEA-0400 Preparation Products And Raw materials |
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