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Product Name:15-keto-17-phenyl trinor prostaglandin F2α
CAS:949564-89-0
Purity:98% Package:1G;10G;100G
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Product Name:15-keto-17-phenyl trinor Prostaglandin F2α
CAS:949564-89-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
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Product Name:15-keto-17-phenyl trinor Prostaglandin F2α
CAS:949564-89-0
Purity:98% Package:1mg;5mg;10mg
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Product Name:15-keto-17-phenyl trinor Prostaglandin F2α
CAS:949564-89-0
Purity:详情请点击官网 Package:1 mg
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| | 15-keto-17-phenyl trinor Prostaglandin F2α Basic information |
| Product Name: | 15-keto-17-phenyl trinor Prostaglandin F2α | | Synonyms: | 15-keto-17-phenyl trinor Prostaglandin F2α;HHEYLKRDELKWGI-RKJYIPPQSA-N;(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-oxo-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoic acid;15-keto-17-phenyl trinor Prostaglandin F2α;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]cyclopentyl]-, (5Z)-;9α,11α-dihydroxy-15-oxo-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oicacid | | CAS: | 949564-89-0 | | MF: | C23H30O5 | | MW: | 386.48 | | EINECS: | | | Product Categories: | | | Mol File: | 949564-89-0.mol |  |
| | 15-keto-17-phenyl trinor Prostaglandin F2α Chemical Properties |
| Boiling point | 594.2±50.0 °C(Predicted) | | density | 1.216±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 2.5 mg/ml | | pka | 4.76±0.10(Predicted) |
| | 15-keto-17-phenyl trinor Prostaglandin F2α Usage And Synthesis |
| Description | Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.1 Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye.2 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 μg/eye. | | References | 1. Cantor, L.B. Bimatoprost: a member of a new class of agents, the prostamides, for glaucoma management Expert Opin. Investig. Drugs 10,721-731(2001).
2. Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment Drugs Future 17(8),691-704(1992). |
| | 15-keto-17-phenyl trinor Prostaglandin F2α Preparation Products And Raw materials |
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