| Company Name: |
Shanghai Xingui Biotechnology Co., Ltd.
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| Tel: |
17501653715 |
| Email: |
xingui2022@126.com |
| Products Intro: |
Product Name:CAY10614
CAS:1202208-36-3
Purity:98% Package:10g,25g,50g,100g,250g,500g,1kg,5kg,10kg……
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CAY10614
CAS:1202208-36-3
Purity:98% Package:1G;10G;100G Remarks:Lipid A is a lipid component of an endotoxin held responsible for the toxicity of gram-negative bacteria. It is the innermost of the three regions of the lipopolysaccharide (LPS), also called endotoxi
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CAY10614 manufacturers
- CAY10614
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- $138.00 / 1mg
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2024-11-19
- CAS:1202208-36-3
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | CAY10614 Basic information |
| Product Name: | CAY10614 | | Synonyms: | CAY10614;N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide;CAY10614 Exclusive;cyclopentyl-[[3,4-di(tetradecoxy)phenyl]methyl]-dimethylazanium:iodide | | CAS: | 1202208-36-3 | | MF: | C42H78INO2 | | MW: | 756 | | EINECS: | | | Product Categories: | | | Mol File: | 1202208-36-3.mol |  |
| | CAY10614 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 0.15 mg/ml; DMSO: 0.14 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | CAY10614 Usage And Synthesis |
| Description | Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC50 value of 1.68 μM in a cell-based assay using modified human embryonic kidney (HEK) cells.1 It does not significantly affect HEK cell viability. In a model of sepsis, CAY10614 dramatically and significantly improves survival of mice given intraperitoneal LPS.1 | | References | 1. Piazza, M., Rossini, C., Fiorentina, S.D., et al. Glycolipids and benzylammonium lipids as novel antisepsis agents: Synthesis and biological characterization J. Med. Chem. 52(4),1209-1213(2009). |
| | CAY10614 Preparation Products And Raw materials |
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