| Company Name: |
BOC Sciences
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| Tel: |
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| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Trap 101
CAS:1216621-00-9
Purity:≥98% by HPLC Remarks:Trap 101 is a potent and selective nociceptin/orphanin FQ (NOP) receptor antagonist (pA2 = 7.75) with selectivity for NOP receptors over classical opioid receptors (pKi = 8.65, 6.60, 6.14 and < 5 for
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| Company Name: |
Jinan ponder chemical co. LTD
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| Tel: |
0531-0000 |
| Email: |
thinklifescience@163.com |
| Products Intro: |
Product Name:1216621-00-9
CAS:1216621-00-9
Purity:99% HPLC Package:1KG;500G;100G；50G;1G
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:Trap-101 hydrochloride >=98% (HPLC), powder
CAS:1216621-00-9
Purity:98% (HPLC), powder Package:25mg;5mg Remarks:NULL
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| | 1-(1-(cyclooctylMethyl)-5-(hydroxyMethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1H-benzo[d]iMidazol-2(3H)-one hydrochloride Basic information |
| | 1-(1-(cyclooctylMethyl)-5-(hydroxyMethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1H-benzo[d]iMidazol-2(3H)-one hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: ≥10mg/mL | | form | powder | | color | white to off-white |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| | 1-(1-(cyclooctylMethyl)-5-(hydroxyMethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1H-benzo[d]iMidazol-2(3H)-one hydrochloride Usage And Synthesis |
| Uses | Trap 101 is a useful intermediate and used to study protein-coupled receptor | | Biological Activity | Trap-101 hydrochloride is a potent, selective and competitive antagonist of NOP receptors, with selectivity for NOP receptors over other opioid receptors. Trap-101 stimulated GTPγ35S binding to CHOhNOP with pKi values of 8.65, 6.60, 6.14 and <5 for NOP, μ-, κ- and δ opioid receptors, respectively. Trap-101 attenuates motor deficits in Parkinson's disease rats and can be used for neurological disease research. | | in vitro | Trap-101 hydrochloride (3, 30, and 300 nM) is inactive per se up to 10 μM, while in the range 3-300 nM, it produces a concentration dependent rightward shift of the concentration-response curve to N/OFQ without modifications of the maximal response to the agonist. Receptor binding affinities of Trap101 (pK i values) at recombinant human NOP, and classical opioid receptors expressed in CHO cell membranes are 8.65, 6.60, 6.14 and < 5 for NOP, μ-, κ-, and δ-opioid receptors respectively. | | target | pKi: 8.65 (NOP receptor); 6.60 (μ-opioid receptor); 6.14 (κ-opioid receptor); < 5 (δ-opioid receptor) |
| | 1-(1-(cyclooctylMethyl)-5-(hydroxyMethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1H-benzo[d]iMidazol-2(3H)-one hydrochloride Preparation Products And Raw materials |
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