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| | BMS-687453 Basic information |
| Product Name: | BMS-687453 | | Synonyms: | BMS-687453;N-[[3-[[2-(4-Chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)glycine;N-(3-{[2-(4-Chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)-N-(methoxycarbonyl)glycine;2-[[3-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-methoxycarbonylamino]acetic acid;CS-1533;BMS-687453;BMS687453;BMS 687453;Glycine, N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)-;BMS-687453,PPAR,Peroxisome proliferator-activated receptors,Inhibitor,BMS687453,inhibit,BMS 687453 | | CAS: | 1000998-59-3 | | MF: | C22H21ClN2O6 | | MW: | 444.86 | | EINECS: | | | Product Categories: | | | Mol File: | 1000998-59-3.mol |  |
| | BMS-687453 Chemical Properties |
| Boiling point | 642.7±65.0 °C(Predicted) | | density | 1.342±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Soluble in DMSO | | form | A crystalline solid | | pka | 3.93±0.10(Predicted) | | color | White to off-white |
| | BMS-687453 Usage And Synthesis |
| Biological Activity | bms 687453 is a pparα agonist.the peroxisome proliferator activated receptor (ppar) is a member of the intracellular nuclear hormone receptor superfamily of transcription factors, having pleiotropic effects on plasma lipoprotein levels, insulin sensitization, atherosclerosis, and inflammation. | | in vitro | bms-687453 was identified as a potent and selective ppar alpha agonist, with approximately 410-fold selectivity versus human ppargamma in ppar-gal4 transactivation assays. in addition, similar potency and selectivity were also seen in the full length receptor co-transfection assays. [1]. | | in vivo | in previous study, bms-687453 had an excellent pharmacokinetic profile across all tested animal species. the oral absorption was rapid in mouse, rat, dog, and cynomulgus monkey. bms-687453 also exhibited low plasma clearance in the mouse, rat, and monkey and moderate plasma clearance in the dog. the half-life of bms-687453 ranged from 3 h in mouse to 12 h in cynomolgus monkeys. bms-687453 showed excellent absolute oral bioavailability ranging from 58% (dog) to 91% (rat) [1]. | | IC 50 | 10 nm for human pparα | | references | [1] li j. discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl) amino)acetic acid (bms-687453). j med chem. 2010 apr 8;53(7):2854-64. |
| | BMS-687453 Preparation Products And Raw materials |
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