D-鞘氨醇
中文名称 | D-鞘氨醇 |
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中文同义词 | D-神经鞘氨醇(牛);D-鞘氨醇;D-神经鞘氨醇;D-赤型神经胺;神經胺醇;D-赤-鞘氨醇;(2S,3R,4E)-2-氨基-4-十八碳烯-1,3-二醇;D-赤式-鞘氨醇 |
英文名称 | D-ERYTHRO-SPHINGOSINE |
英文同义词 | SPHINGOSINE, C18 CHAIN;TRANS D-THREO-SPHINGOSINE;TRANS D-ERYTHRO-SPHINGOSINE;TRANS-D-ERYTHRO-2-AMINO-4-OCTADECENE-1,3-DIOL;BRAIN SPHINGOSINE;BRAIN, BOVINE;EGG SPHINGOSINE;D-SPHINGOSINE (BOVINE) |
CAS号 | 123-78-4 |
分子式 | C18H37NO2 |
分子量 | 299.49 |
EINECS号 | 204-651-3 |
相关类别 | 原料药;其他科研原料药;脂类;抗体-二抗;常用糖合成中间体;Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols;Inhibitors;Protein Kinase Inhibitors and Activators;Protein Kinase;Amines;糖脂 |
Mol文件 | 123-78-4.mol |
结构式 | ![]() |
D-鞘氨醇 性质
熔点 | 74.2-78.1 °C |
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沸点 | 440.8°C (rough estimate) |
密度 | 0.9758 (rough estimate) |
折射率 | 1.5000 (estimate) |
储存条件 | -20°C |
溶解度 | 氯仿:20 mg/mL,澄清,无色至微黄色 |
酸度系数(pKa) | 11.80±0.45(Predicted) |
形态 | 粉末或蜡状固体 |
颜色 | 白色至奶油色 |
Merck | 14,8747 |
BRN | 1727294 |
稳定性 | 稳定的。与强酸、强碱、强氧化剂不相容。 |
InChIKey | WWUZIQQURGPMPG-KRWOKUGFSA-N |
CAS 数据库 | 123-78-4 |
p32 8 μM (EC 50 ) |
PKC
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PP2A
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Human Endogenous Metabolite
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A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines. D-erythro-Sphingosine inhibits protein kinase C in vitro. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells.
提供商 | 语言 |
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英文
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