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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Products Intro: |
Product Name:Amidepsine D
CAS:79786-34-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | AMidepsine D Basic information |
| Product Name: | AMidepsine D | | Synonyms: | AMidepsine D;4-[(2,4-Dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-benzoic acid 4-carboxy-3-hydroxy-5-methylphenyl ester;2,4-di-O-methylgyrophoric acid;Benzoic acid, 4-[(2,4-dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-, 4-carboxy-3-hydroxy-5-methylphenyl ester;Amidepsin D;Amidepsine D, DGAT inhibitor | | CAS: | 79786-34-8 | | MF: | C26H24O10 | | MW: | 496.46 | | EINECS: | | | Product Categories: | | | Mol File: | 79786-34-8.mol |  |
| | AMidepsine D Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | crystalline solid | | color | White to light pink |
| | AMidepsine D Usage And Synthesis |
| Uses | Amidepsine D is a fungal metabolite isolated from the culture broth of Humicola sp, which inhibits DGAT activity, thus triacylglycerol formation is attenuated and protects against the development of diet-induced obesity or insulin-resistance. | | Biological Activity | amidepsine d is a fungal metabolite isolated from the culture broth of humicola sp fo-2942. amidepsine a is an inhibitor of dylglycerol acyltransferase (dgat).dylglycerol acyltransferase (dgat) has been involved in catalyzing the formation of triglycerides from diacylglycerol and acyl-coa. the reaction is considered the terminal and only committed step in triglyceride synthesis and is essential for the formation of adipose tissue. there are two isozymes of dgat have been identified: dgat1 and dgat2. dgat-1 deficient mice are lean and resistant to the development of diet-induced obesity or insulin resistance [1]. dgat2-/- mice demonstrate reduced triglyceride levels and suffer from skin barrier abnormalities [2].fo-2942 inhibited dgat activity with an ic50 of 10.2 μm in rat liver microsomes. fo-2942 inhibited triacylglycerol formation in raji cells with the ic50 value of 15.5 μm [1]. | | storage | +4°C | | references | [1] tomoda h, tabata n, ito m, et al. amidepsines, inhibitors of diacylglycerol acyltransferase produced by humicola sp. fo-2942[j]. the journal of antibiotics, 1995, 48(9): 942-947.
[2] smith s j, cases s, jensen d r, et al. obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking dgat[j]. nature genetics, 2000, 25(1): 87-90.
[3] stone s j, myers h m, watkins s m, et al. lipopenia and skin barrier abnormalities in dgat2-deficient mice[j]. journal of biological chemistry, 2004, 279(12): 11767-11776. |
| | AMidepsine D Preparation Products And Raw materials |
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