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Gefitinib-d6

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Gefitinib-d6 Suppliers list
Company Name: S.Z. PhyStandard Bio-Tech. Co., Ltd.  
Tel: 0755-4000505016 13380397412
Email: 3001272453@qq.com
Products Intro: Product Name:Gefitinib-d6
CAS:1228664-49-0
Purity:99% HPLC Package:10mg;25mg;50mg;100mg
Company Name: Nanjing XiZe Biotechnology CO., Ltd.  
Tel: 025-58362220 15250997978
Email: 1511893459@qq.com
Products Intro: Product Name:Gefitinib-d6
CAS:1228664-49-0
Purity:95% HPLC Package:10mg;25mg;50mg;100mg;250mg;500mg;1g
Company Name: Shenzhen Polymeri Biochemical Technology Co., Ltd.  
Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Products Intro: Product Name:Gefitinib-d6
CAS:1228664-49-0
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:Gefitinib-d6
CAS:1228664-49-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Cato Research Chemicals Inc.  
Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Products Intro: Product Name:Gefitinib-d6
CAS:1228664-49-0
Purity:95%（HPLC） Package:10mg；25mg；50mg；100mg
Gefitinib-d6 Basic information
Product Name:Gefitinib-d6
Synonyms:Gefitinib-d6;Hexadeuterated gefitinib;[2H6]-Gefitinib;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
CAS:1228664-49-0
MF:C22H24ClFN4O3
MW:446.91
EINECS:
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Mol File:1228664-49-0.mol
Gefitinib-d6 Structure
Gefitinib-d6 Chemical Properties
storage temp. Store at -20°C
solubility DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml
form A solid
color White to off-white
Safety Information
MSDS Information
Gefitinib-d6 Usage And Synthesis
DescriptionGefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).
UsesGefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.
Gefitinib-d6 Preparation Products And Raw materials
Tag:Gefitinib-d6(1228664-49-0) Related Product Information
4-(3-Chloropropyl)morpholine 4,4'-(propane-1,3-diyl)bismorpholine Gefitinib N-Oxide 4-Defluoro-4-hydroxy Gefitinib Gefitinib 3-Hydroxy-4-methoxybenzonitrile 3-Chloro-4-fluoroaniline 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one 2-aMino-4-Methoxy-5-(3-Morpholinopropoxy)benzaMide 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one 3,4-Dichloroaniline N-(3-chloro-4-fluorophenyl)-7 -methoxy-6-(3-morpholinopropoxy)-N-(3-morpholinopropyl)quinazolin-4-amine Gefitinib 3,4-Difluoro Impurity HCl 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol 3-Deschloro-4-Desfluoro-4-Chloro-3-Fluorogefitinib 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate