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Syntechem Co.,Ltd
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Product Name:(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide
CAS:848193-72-6
Purity:97% Package:1g;5g;25g;100g;250g;1kg;5kg;10kg;25kg Remarks:we offer low price custom synthesis and contract manufacturing
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Sigma-Aldrich
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Product Name:CHIC-35
CAS:848193-72-6
Purity:>=97% (chiral, HPLC) Package:5MG Remarks:C8742-5MG
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TargetMol Chemicals Inc.
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4008200310 |
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marketing@tsbiochem.com |
| Products Intro: |
Product Name:CHIC35;CHIC35
CAS:848193-72-6
Purity:98% Package:10 mg;25 mg
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| | (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Basic information |
| Product Name: | (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide | | Synonyms: | (6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide;CHIC-35;Compound (S)-35;SIRT1 Inhibitor IV, (S)-35;(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide;SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem;Cyclohept[b]indole-6-carboxamide, 2-chloro-5,6,7,8,9,10-hexahydro-, (6S)- | | CAS: | 848193-72-6 | | MF: | C14H15ClN2O | | MW: | 262.73 | | EINECS: | | | Product Categories: | | | Mol File: | 848193-72-6.mol | ![(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Structure](CAS/20150408/GIF/848193-72-6.gif) |
| | (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | solid |
| Hazard Codes | Xn | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| | (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Usage And Synthesis |
| Definition | ChEBI: CHIC-35 is an organic heterotricyclic compound resulting from the formal fusion of the 2-3 bond of 5-chloroindole with the 2-3 bond of cycloheptanecarboxamide (the S enantiomer). It is a potent, cell-permeable, metabolically stable and selective inhibitor of the deacetylase SIRT1. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor. It is an aromatic compound, an organic heterotricyclic compound, an organochlorine compound and a primary carboxamide. | | General Description | A cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322). Shown to be orally bioavailable with a serum half-life of 94 minutes in mice in vivo. | | Biochem/physiol Actions | CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging. |
| | (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Preparation Products And Raw materials |
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