| Company Name: |
MedChemexpress LLC
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:Deltarasin (hydrochloride)
CAS:1440898-82-7
Purity:>98% Package:1116RMB/2mg
|
| Company Name: |
LETOPHARM LIMITED
|
| Tel: |
+86-21-5821 5861 |
| Email: |
sales@letopharm.com |
| Products Intro: |
Product Name:Deltarasin (hydrochloride)
CAS:1440898-82-7
|
| Company Name: |
Guangzhou QiYun Biotechnology Co., Ltd.
|
| Tel: |
020-61288194 61288195 |
| Email: |
505721671@qq.com |
| Products Intro: |
Product Name:Deltarasin (hydrochloride)
CAS:1440898-82-7
Purity:98% Package:8277RMB/50mg
|
|
| | Deltarasin (hydrochloride) Basic information |
| Product Name: | Deltarasin (hydrochloride) | | Synonyms: | Deltarasin (hydrochloride);Deltarasin hydrochloride (1:?);Deltarasin trihydrochloride;2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride | | CAS: | 1440898-82-7 | | MF: | C40H40Cl3N5O | | MW: | 713.1375 | | EINECS: | | | Product Categories: | | | Mol File: | 1440898-82-7.mol |  |
| | Deltarasin (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | crystalline solid |
| | Deltarasin (hydrochloride) Usage And Synthesis |
| Uses | Deltarasin (cas# 1440898-82-7) is a useful research chemical.Deltarasin was used as a reagent in studying small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. | | Biological Activity | deltarasin hydrochloride is a selective inhibitor of kras-pdeδ interaction with ic50 value of 41±12 nm [1].kras, also known as v-ki-ras2 kirsten rat sarcoma viral oncogene homolog, is a protein and works as a molecular on/off switch whose mutant is an essential step in the development of many cancers. pdeδ (prenyl binding protein) controls the spatial organization of k-ras, which enhances ras diffusion in the cytosol. inhibition of the ras-pdeδ interaction by small molecules impairs ras localization and signaling has becoming a promising strategy to treat cancers in clinic [1, 2].deltarasin hydrochloride is a potent kras-pdeδ interaction inhibitor. when tested with human pancreatic ductal adenocarcinoma cells deltarasin hydrochloride showed inhibition on kras-pdeδ interaction to inhibit oncogenic ras signaling and suppressed cell proliferation by binding to pdeδ with kd value of 41 nm [1].in nude mice model with panc-tu-i xenograft, administration of deltarasin hydrochloride (10, 15 mg/kg) impaired cells growth and decreased tumor volume after 9 days in a dose-dependent manner [1]. | | storage | Store at -20°C | | references | [1]. zimmermann, g., et al., small molecule inhibition of the kras-pdedelta interaction impairs oncogenic kras signalling. nature, 2013. 497(7451): p. 638-42.
[2]. the kras-pdedelta interaction is a therapeutic target. cancer discov, 2013. 3(7): p. of20. |
| | Deltarasin (hydrochloride) Preparation Products And Raw materials |
|