4(二(1H-吲哚-3-基)甲基)苯酚
| 中文名称 | 4(二(1H-吲哚-3-基)甲基)苯酚 |
|---|---|
| 中文同义词 | 4(二(1H-吲哚-3-基)甲基)苯酚;化合物DIM-C-PPHOH;DIM-C-PPHOH,NUR77拮抗剂 |
| 英文名称 | 4-(di(1H-indol-3-yl)Methyl)phenol |
| 英文同义词 | 4-(di(1H-indol-3-yl)Methyl)phenol;DIM-C-pPhOH;4-[bis(1H-indol-3-yl)methyl]phenol;C-DIM8;1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane;DIM-C-pPhOH(CDIM8);Phenol, 4-(di-1H-indol-3-ylmethyl)-;inhibit,receptor,Inhibitor,β1-integrin,mTOR,cancer,DIMCpPhOH,signaling,nuclear,xenografts,Apoptosis,DIM C pPhOH,stress |
| CAS号 | 151358-47-3 |
| 分子式 | C23H18N2O |
| 分子量 | 338.4 |
| EINECS号 | |
| 相关类别 | 吲哚类 |
| Mol文件 | 151358-47-3.mol |
| 结构式 |  |
4(二(1H-吲哚-3-基)甲基)苯酚 性质
| 熔点 | 122-124 °C |
|---|---|
| 沸点 | 610.2±50.0 °C(Predicted) |
| 密度 | 1.321±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 溶于 DMSO (35 mg/ml)；乙醇（35 毫克/毫升） |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.98±0.26(Predicted) |
| 颜色 | 粉色 |
| 稳定性 | 自购买之日起 2 年内保持稳定。 DMSO 溶液可在 -20°C 下保存长达 2 个月。 |
| Target | Value |
|
Nur77
(786-O cells based assay) | 13.0 μM |
|
Nur77
(ACHN cells based assay) | 13.6 μM |
DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.
DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.
DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.
DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines.
Cell Proliferation Assay
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 7.5 μM, 15 μM, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Significantly decreased cell proliferation. |
Apoptosis Analysis
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 20 μM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis in ACHN and 786-O cells. |
Western Blot Analysis
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 15 μM, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induced sestrin 2, activated AMPKα and inhibited activation of mTOR and downstream kinases. |
DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth.
| Animal Model: | Male athymic nude mice (aged 6-7 weeks) injected with ACHN cells |
| Dosage: | 30 mg/kg/day |
| Administration: | Oral gavage; daily; for 50 days |
| Result: | Resulted in a significant inhibition of tumor growth. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-112055 | 4(二(1H-吲哚-3-基)甲基)苯酚 DIM-C-pPhOH | 151358-47-3 | 1mg | 500元 |
| 2024/08/19 | HY-112055 | 4(二(1H-吲哚-3-基)甲基)苯酚 DIM-C-pPhOH | 151358-47-3 | 5mg | 750元 |