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2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide

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2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide Suppliers list
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:hSMG-1 inhibitor 11j
CAS:1402452-15-6
Purity:99.29% Package:1mg;163USD|2mg;243USD|5mg;413USD
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
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Products Intro: Product Name:hSMG-1 inhibitor 11j
CAS:1402452-15-6
Purity:99% Package:$500.9/5mg;$850.9/10mg;Bulk package Remarks:99%
Company Name: Nantong HI-FUTURE Biology Co., Ltd.  
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Products Intro: Product Name:hSMG-1 inhibitor 11j
CAS:1402452-15-6
Purity:0.98 Package:5mg，10mg，100mg，500mg，1g，5g，10g
Company Name: J & K SCIENTIFIC LTD.  
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Products Intro: Product Name:2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide
CAS:1402452-15-6
Package:2.5Mg,25Mg
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Products Intro: Product Name:Pyrimidine Related Compound 1
CAS:1402452-15-6
Purity:> 95% Remarks:An impuritiy of Pyrimethamine.Pyrimethamine can be used with leucovorin to treat toxoplasmosis and c

2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide manufacturers

  • hSMG-1 inhibitor 11j
  • hSMG-1 inhibitor 11j pictures
  • $163.00 / 1mg
  • 2024-11-20
  • CAS:1402452-15-6
  • Min. Order:
  • Purity: 99.29%
  • Supply Ability: 10g
2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide Basic information
Product Name:2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide
Synonyms:2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide;Pyrimidine Related Compound 1;ap261133;Benzenesulfonamide, 2-chloro-N,N-diethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]-;hSMG-1 inhibitor 11j;hSMG 1 inhibitor 11j,hSMG1 inhibitor 11j;2-Chloro-N,N-diethyl-5-((4-(2-(4-(3-methylureido)phenyl)pyridin-4-yl)pyrimidin-2-yl)amino)benzenesulfonamide
CAS:1402452-15-6
MF:C27H28ClN7O3S
MW:566.07
EINECS:
Product Categories:Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Mol File:1402452-15-6.mol
2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide Structure
2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide Chemical Properties
density 1.353±0.06 g/cm3(Predicted)
storage temp. 4°C, away from moisture and light
solubility DMSO: 2mg/mL, clear
form Solid
pka14.00±0.46(Predicted)
color White to yellow
Safety Information
MSDS Information
2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide Usage And Synthesis
Uses2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]benzenesulfonamide are pyrimidine derivatives as hSMG-1 inhibitors.
Biological ActivityPotent and selective SMG-1 (hSMG-1; SMG1) kinase inhibitor th at blocks nonsense-mediated decay (NMD).


SMG1i is a potent and selective SMG-1 kinase inhibitor (hSMG-1 IC50 = 110 pM) with much reduced potency against mTOR, PI3Kα/γ and CDK1/2 (IC50 = 50 nM, 92/60 nM, 32/7.1 μM, respectively). SMG1i selectively downregulates MDA361 cellular phosphorylation of UPF1 (0.3 -1 μM), but not th at of mTOR or AKT substrates (p70s6 K and PI3K). Nonsense-mediated decay (NMD) inhibition by SMG1i (1 μM) is shown to synergize with premature termination codons (PTCs) readthrough agents (G418, gentamicin, and paromomycin) in promoting the expression of CFTR protein in murine cells carrying Cftr G542X nonsense mutation.
2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide Preparation Products And Raw materials
Tag:2-Chloro-N,N-diethyl-5-[[4-[2-[4-[[(MethylaMino)carbonyl]aMino]phenyl]-4-pyridinyl]-2-pyriMidinyl]aMino]benzenesulfonaMide(1402452-15-6) Related Product Information