| Company Name: |
Levena (Suzhou) Biopharma Co., Ltd. Gold
|
| Tel: |
0512-81877925 051281877925 |
| Email: |
info@levena.cn |
| Products Intro: |
Product Name:D8-Monomethyl auristatin E
CAS:2070009-72-0
Purity:>99% Package:1mg/RMB 8000;5mg/RMB 20000;10mg/RMB 35000
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| Company Name: |
Haoyuan Chemexpress Co., Ltd.
|
| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:D8-MMAE
Purity:>98% Package:5500RMB/1mg
|
D8-MMAE manufacturers
- D8-MMAE
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- $0.00 / 1mg
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2021-09-16
- CAS:2070009-72-0
- Min. Order: 1mg
- Purity: 99%
- Supply Ability: 100KG
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| | D8-MMAE Basic information |
| Product Name: | D8-MMAE | | Synonyms: | D8-MMAE;D8-Monomethyl auristatin E;MMAE-d8;2H8]-MMAE;MMAE-d-8,MMAE d8,MMAEd8 | | CAS: | 2070009-72-0 | | MF: | C39H59D8N5O7 | | MW: | 726.027874224 | | EINECS: | | | Product Categories: | | | Mol File: | 2070009-72-0.mol |  |
| | D8-MMAE Chemical Properties |
| storage temp. | Store at -20°C,unstable in solution, ready to use. | | solubility | DMSO : 100 mg/mL (137.74 mM; Need ultrasonic) | | form | Solid | | color | White to off-white |
| | D8-MMAE Usage And Synthesis |
| Biological Activity | D8-MMAE (D8-Monomethyl auristatin E) is a deuterated labeled MMAE. MMAE is a tubulin inhibitor that inhibits mitosis. | | in vivo | Intratumoral MMAE concentrations consistently correlates with the extent of tumor growth inhibition in tumor xenograft models. IHC analysis reveals that nonbinding control-treated tumors consist of both CD30 + and CD30 - cells, presumably because they do not kill either CD30 + or CD30 - Karpas 299 cells. Only CD30 - cells are found in cAC10-vcMMAF-treated tumors, illustrating that cAC10-vcMMAF eliminates most CD30 + cells. Interestingly, the two tumors that relapses from cAC10-vcMMAE treatment are also found to be CD30 - by the end of study, indicating a small fraction of CD30 - cells might have escaped from bystander killing in these two remaining tumors. p> | | target | |
| | D8-MMAE Preparation Products And Raw materials |
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