| Company Name: |
SPIRO PHARMA
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| Email: |
eric_feng1954@126.com |
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Product Name:Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]-
CAS:1431411-66-3
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
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| Company Name: |
ShangHai Biochempartner Co.,Ltd
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17754423994 17754423994 |
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2853530910@QQ.com |
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Product Name:SIRT-IN-2
CAS:1431411-66-3
Purity:98% HPLC LCMS Package:100MG;1G
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| Company Name: |
Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312 |
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liming@bio-fount.com |
| Products Intro: |
Product Name:Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]-
CAS:1431411-66-3
Purity:97.0% Package:5mg
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| | Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- Basic information |
| Product Name: | Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- | | Synonyms: | Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]-;4-[4-[2-[(methylsulfonyl)amino]ethyl]-1-piperidinyl]-Thieno[3,2-d]pyrimidine-6-carboxamide;4-[4-[2-(methanesulfonamido)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxamide;SIRT-IN-2;Inhibitor,SIRT IN 2,inhibit,Sirtuin,SIRTIN2 | | CAS: | 1431411-66-3 | | MF: | C15H21N5O3S2 | | MW: | 383.49 | | EINECS: | | | Product Categories: | | | Mol File: | 1431411-66-3.mol | ![Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- Structure](CAS/20150408/GIF/1431411-66-3.gif) |
| | Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | color | Yellow to brown |
| | Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- Usage And Synthesis |
| Description | SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively. SIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1]. | | References | [1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79. |
| | Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(Methylsulfonyl)aMino]ethyl]-1-piperidinyl]- Preparation Products And Raw materials |
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