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EMMX Biotechnology LLC
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888-539-0666 |
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info@emmx.com |
Products Intro: |
Product Name:BMS 753 CAS:215307-86-1 Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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Company Name: |
Shanghai Chaolan Chemical Technology Center
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Tel: |
QQ:65489617 15618227136 |
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info@SuperLan-chem.com |
Products Intro: |
Product Name:BMS 753 CAS:215307-86-1 Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Basic information |
Product Name: | 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid | Synonyms: | Benzoic acid, 4-[[(2,3-dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-;4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoate | CAS: | 215307-86-1 | MF: | C21H21NO4 | MW: | 351.4 | EINECS: | | Product Categories: | | Mol File: | 215307-86-1.mol | |
| 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Chemical Properties |
Boiling point | 482.2±45.0 °C(Predicted) | density | 1.240±0.06 g/cm3(Predicted) | storage temp. | 2-8°C | solubility | DMSO: ≥5mg/mL | pka | 4.26±0.10(Predicted) | form | powder | color | white to beige |
Hazard Codes | Xn | Risk Statements | 22 | WGK Germany | 3 |
| 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Usage And Synthesis |
Uses | BMS 753 is as been reported to be a RARα-selective agonist. Used to develop a series of small molecule inhibitors which affect specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease. This would aspire to reduce the attrition problem in drug discovery. | Biological Activity | BMS 753 is a subtype-selective retinoic acid receptor alpha (RARα) agonist with a Ki value of 2 nM for RARα. | in vitro | BMS 753 results in low levels of RARβ transcripts in WT cells, RARγ -/- , but not activates in RARa -/- cells. | target | | storage | Store at RT |
| 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]-benzoic acid Preparation Products And Raw materials |
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