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1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Email: ivan@atkchemical.com
Products Intro: Product Name:A 1070722
CAS:1384424-80-9
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:A 1070722
CAS:1384424-80-9
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
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Products Intro: Product Name:A 1070722
CAS:1384424-80-9
Purity:98% Package:$124.9/10mg;$429.9/50mg;$1935.9/250mg;Bulk package Remarks:98%
Company Name: Sichuan Wei Keqi Biological Technology Co., Ltd.  
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Products Intro: Product Name:A1070722
CAS:1384424-80-9
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
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Products Intro: Product Name:A 1070722
CAS:1384424-80-9
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Basic information
Product Name:1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Synonyms:1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea;A-1070722;N-(7-Methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]urea;-[6-(trifluoromethyl)-2-pyridinyl]urea;N-(7-Methoxy-4-quinolinyl)-N’Urea, N-(7-methoxy-4-quinolinyl)-N'-[6-(trifluoromethyl)-2-pyridinyl]-;A 1070722,Glycogen synthase kinase-3,inhibit,A1070722,Inhibitor,GSK-3,Glycogen synthase kinase 3,A-1070722
CAS:1384424-80-9
MF:C17H13F3N4O2
MW:362.31
EINECS:
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Mol File:1384424-80-9.mol
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Structure
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Chemical Properties
Boiling point 412.5±45.0 °C(Predicted)
density 1.461±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble15mg/mL, clear
pka11.57±0.43(Predicted)
form powder
color white to beige
Safety Information
Hazard Codes T
Risk Statements 25-36/37/38
Safety Statements 36/37/39-45
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
MSDS Information
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Usage And Synthesis
DescriptionA-1070722 is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = <100 nM).
UsesN-(7-Methoxy-4-quinolinyl)-N''-[6-(trifluoromethyl)-2-pyridinyl]urea is a neuroprotective agent and a glycogen synthase kinase-3 (GSK-3) inhibitor. GSK-3 is a conserved signaling enzyme that regulates a wide range of biological events (apoptosis, synaptic plasticity, axon formation, and neurogenesis). The enzyme has a conserved catalytic domain for binding ATP and a C-terminal domain with a conserved activation loop for the kinase activity. GSK-3 is a therapeutic target for treating neurodegenerative and psychiatric disorders.
storageStore at RT
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea Preparation Products And Raw materials
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