TC ASK 10 manufacturers
- TC ASK 10
-
- $29.00 / 1mg
-
2024-11-14
- CAS:1005775-56-3
- Min. Order:
- Purity: 99.71%
- Supply Ability: 10g
- TC ASK 10
-
- $29.00 / 1mg
-
2024-11-14
- CAS:1005775-56-3
- Min. Order:
- Purity: 99.71%
- Supply Ability: 10g
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| | TC ASK 10 Basic information |
| Product Name: | TC ASK 10 | | Synonyms: | TC ASK 10;ASK1 Inhibitor 10;4-tert-butyl-N-(6-imidazol-1-ylimidazo[1,2-a]pyridin-2-yl)benzamide:hydrochloride;4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride;Apoptosis,ASK1,oral,MAP3K,bioavailability,TC ASK-10,TC ASK10,Inhibitor,pharmacokinetic,JNK,TC ASK 10,p38,inhibit,selective,MAP kinase kinase kinase, MEKK, MAPKKK,Phosphorylation;N-(6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-(tert-butyl)benzamide dihydrochloride | | CAS: | 1005775-56-3 | | MF: | C21H22ClN5O | | MW: | 395.89 | | EINECS: | | | Product Categories: | | | Mol File: | 1005775-56-3.mol |  |
| | TC ASK 10 Chemical Properties |
| Melting point | >270° (dec.) | | storage temp. | Refrigerator, under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White |
| | TC ASK 10 Usage And Synthesis |
| Description | ASK1 inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC50 = 14 nM). It is selective for ASK1 over ASK2 (IC50 = 510 nM) as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF (IC50s = >10,000 nM for all). It inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner. | | Uses | TC ASK 10 is a potent ASK1 inhibitor. It displays selectivity for ASK1 over other kinases including ASK2, MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf. It blocks downstream JNK1/p38 phosphorylation in cells. | | storage | Desiccate at RT |
| | TC ASK 10 Preparation Products And Raw materials |
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