| Company Name: |
MedChemexpress LLC
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:TH287 (hydrochloride)
CAS:1638211-05-8
Purity:>98% Package:750RMB/5mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
021-021-33632979 15002134094 |
| Email: |
marketing@targetmol.com |
| Products Intro: |
Product Name:TH287 hydrochloride
CAS:1638211-05-8
Package:10 mg;2 mg;25 mg;5 mg
|
|
| | TH287 (hydrochloride) Basic information |
| | TH287 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | TH287 (hydrochloride) Usage And Synthesis |
| Description | TH287 hydrochloride is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies.
| | References | [1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21. |
| | TH287 (hydrochloride) Preparation Products And Raw materials |
|